Bosentas Tablet (Bosentan)

Precautions Of Bosentas Tablet (Bosentan)

• Liver monitoring required: Can cause elevation of liver enzymes. Regular LFTs (Liver Function Tests) are mandatory.
• Pregnancy warning: Not safe during pregnancy. Can cause birth defects. Effective contraception needed.
• Not for breastfeeding mothers.
• Avoid if you have liver disease.
• May decrease sperm count in men.
• Can interact with many medications — use only under medical supervision.
• Avoid alcohol as it increases liver risk.
• Do not stop the medicine suddenly without medical advice.

Uses of Bosentas Tablet (Bosentan)

• Treatment of Pulmonary Arterial Hypertension (PAH) (WHO Class II–IV)
• Improves exercise capacity
• Slows the worsening of symptoms
• Helps reduce blood vessel tightening in the lungs

Side Effects Of Bosentas Tablet (Bosentan)

Common:

• Headache
• Flushing
• Ankle swelling
• Low blood pressure
• Respiratory infections
• Palpitations
• Fatigue

FAQs Of Bosentas Tablet (Bosentan)

1. Is Bosentan safe for long-term use?

It can be used long-term with regular liver monitoring.

2. Can pregnant women take Bosentan?

No. It is unsafe during pregnancy and may cause birth defects.

3. How soon does Bosentan work?

Some improvements may be seen in a few weeks, but full benefit can take 2–3 months.

4. Can Bosentan cause liver damage?

Yes, it may increase liver enzymes. Routine liver tests are mandatory.

Interactions Of Bosentas Tablet (Bosentan)

Bosentan may interact with:

• Major interactions
• Cyclosporine – contraindicated
• Glyburide – avoid due to liver toxicity risk

Other interactions

• Hormonal contraceptives (reduces effectiveness)
• Rifampicin
• Ketoconazole
• Simvastatin
• Warfarin
• HIV medicines (lopinavir/ritonavir)