Zubion Veterinary Injection (Buparvaquone) | Used to Treat Theileriosis in Cattle & Livestock

Precaution

1. Veterinary Use Only

Zubion Veterinary Injection is intended for animal use and should not be used in humans. Administration should be performed by or under the direction of a qualified veterinarian.

2. Confirm the Diagnosis

Theileriosis can cause signs that overlap with other tick-borne and blood-borne diseases. The animal should be properly evaluated before treatment.

3. Correct Dose

The dose should be calculated according to the animal's body weight and clinical condition. Do not estimate or change the dose without veterinary advice.

4. Intramuscular Administration Only

Zubion should be administered by the recommended intramuscular route. It should not be administered intravenously or subcutaneously.

5. Injection Site

When a larger volume is required, the recommended amount should be divided between appropriate injection sites rather than injecting more than the recommended volume at a single site.

6. Severe Theileriosis

Severely affected animals may require additional supportive treatment for problems such as anemia, dehydration, fever, or other complications associated with the infection.

7. Supportive Treatment

Veterinary assessment may identify a need for supportive antibacterial, nutritional, anti-inflammatory, fluid, or anemia management depending on the animal's condition.

8. Pregnancy

Limited safety information may be available for pregnant animals. Inform the veterinarian if the animal is pregnant or may be pregnant before treatment.

Usage 

• Use Zubion only under veterinary direction.
• Confirm the animal's body weight before calculating the dose.
• The commonly referenced dose is 2.5 mg Buparvaquone/kg body weight, equivalent to 1 mL per 20 kg body weight of the 50 mg/mL formulation.
• Administer by deep intramuscular injection.
• The neck muscle is a recommended injection site in the product information.
• Do not administer intravenously or subcutaneously.
• Do not inject more than 10 mL at a single site according to the referenced product directions.
• In severe cases, a second dose may be considered 48–72 hours after the first dose according to veterinary assessment.

Uses

1. Tropical Theileriosis

Zubion is used to treat tropical Theileriosis caused by susceptible Theileria species, particularly Theileria annulata.

2. East Coast Fever

Buparvaquone is used against East Coast Fever associated with susceptible Theileria parva infections.

3. Clinical Theileriosis

Zubion can be used in animals showing clinical signs of Theileriosis following appropriate veterinary diagnosis.

4. Theileria Schizont and Piroplasm Stages

Buparvaquone has activity against important schizont and piroplasm stages of Theileria parasites.

5. Theileriosis During the Incubation Period

Product information indicates that Buparvaquone may be used during the incubation period or when clinical signs are already apparent, depending on veterinary assessment.

Side Effects

Common or Local Reactions

• Temporary injection-site discomfort
• Localized swelling
• Localized edema
• Mild sensitivity at the injection site
• Mild pain or discomfort after injection
• Temporary sensitivity at the injection site

The product information specifically reports that localized, painless edematous swelling may occasionally occur at the injection site.

Serious Reactions

Contact a veterinarian promptly if the animal develops:

• Severe swelling at the injection site
• Marked weakness or collapse
• Difficulty breathing
• Severe deterioration after treatment
• Other unexpected or rapidly worsening symptoms
• Rapidly worsening swelling or inflammation at the injection site

FAQs

1. What is Zubion Veterinary Injection?

Zubion is a veterinary antiprotozoal injection containing Buparvaquone 50 mg/mL. It is used primarily for Theileriosis in susceptible animals.

2. What is the generic name of Zubion Injection?

The active ingredient in Zubion is Buparvaquone.

3. What is Zubion Injection used for?

Zubion is used for the treatment of Theileriosis caused by susceptible Theileria species.

4. What strength does Zubion Injection contain?

Zubion contains 50 mg of Buparvaquone per mL, equivalent to a 5% formulation.

5. How does Zubion work?

Buparvaquone interferes with the mitochondrial electron transport system of Theileria parasites, disrupting their energy production and survival.

6. How is Zubion administered?

Zubion is administered by intramuscular injection. It should not be given intravenously or subcutaneously.

7. What is the commonly referenced dose of Zubion?

The commonly referenced dose is 2.5 mg/kg body weight, equivalent to 1 mL per 20 kg for the 50 mg/mL formulation. The veterinarian should determine the appropriate dose for the individual animal.

8. Can Zubion be repeated in severe cases?

Product information indicates that a second dose may be administered 48–72 hours after the first in severe cases when considered necessary by the veterinarian.

Interactions

1. Supportive Antibacterial Treatment

Animals with severe Theileriosis may develop secondary infections. Supportive antibacterial treatment may be considered by the veterinarian when clinically appropriate.

2. Anti-Inflammatory Medicines

Anti-inflammatory medicines may be used as supportive treatment when clinically indicated. The veterinarian should determine whether concurrent treatment is appropriate.

3. Anti-Anemia Treatment

Theileriosis may be associated with anemia. Additional treatment to manage anemia may be required in severely affected animals.

4. Nutritional Support

Proper nutrition can support recovery during convalescence, particularly in animals that have experienced reduced appetite or weakness.

5. Fluid and Electrolyte Therapy

Animals with dehydration or significant systemic illness may require fluid and electrolyte support based on veterinary assessment.

6. Other Antiprotozoal Medicines

Tell the veterinarian about any other antiprotozoal medicines being used. Combining treatments should only be done when specifically recommended.

7. Tick-Control Products

Because Theileriosis is transmitted by ticks, appropriate tick-control and disease-management measures may form part of the overall treatment program.

8. Vaccines

Vaccination should be discussed with the veterinarian during recovery. Product information recommends delaying vaccination until complete recovery in affected animals.