Dyronib Tablet(Dasatinib)

Precautions Of Dyronib Tablet

Before taking Dyronib, inform your doctor if you have any of the following conditions:

• Heart disease, especially a history of heart rhythm disorders (e.g., long QT syndrome) or heart failure.

• Liver disease or impaired liver function.

• Reduced kidney function.

• Low levels of potassium or magnesium in the blood.

• Pregnancy or planning to become pregnant—dasatinib may cause serious harm to the unborn baby.

• Breastfeeding—avoid while on treatment and for 2 weeks after the last dose.

• Children: growth and development may be affected; monitoring is needed.

Also, avoid or use with caution:

• Grapefruit or grapefruit juice (can significantly increase drug levels).

• Antacids, or products with aluminium/magnesium, PPIs/H2 blockers which may reduce absorption.

Usage Of Dyronib Tablet

Dyronib (dasatinib) is used for:

• Newly-diagnosed adults with Philadelphia chromosome-positive (Ph⁺) chronic myeloid leukaemia (CML) in the chronic phase.

• Adults with Ph⁺ CML in chronic, accelerated, or blast phase who have resistance or intolerance to prior therapy (e.g., to Imatinib).

• Adults with Ph⁺ acute lymphoblastic leukaemia (ALL) with resistance or intolerance to prior therapy.

• Paediatric patients (1 year of age and older) with Ph⁺ CML in chronic phase and certain cases of newly diagnosed Ph⁺ ALL in combination with chemotherapy

Side Effects Of Dyronib Tablet

Common side-effects may include:

• Diarrhoea, nausea, vomiting, headache, tiredness.

• Skin rash, muscle pain.

• Shortness of breath, fluid retention (e.g., swelling of ankles/feet).

Serious side-effects (seek medical attention if you notice):

• Bleeding (unusual bruising, bloody/stool, red urine) because of low blood cell counts.

• Heart problems: abnormal heart rate, heart attack, stroke, or transient ischaemic attack.

• Pulmonary arterial hypertension (PAH): unexplained shortness of breath, swelling of legs/feet.

• Liver injury: yellowing of skin/eyes, dark urine, pain in the right upper abdomen.

• Tumour lysis syndrome (TLS) in high tumour-burden cases: rapid breakdown of cancer cells may cause kidney problems or heart rhythm changes.

FAQs Of Dyronib Tablet

Q1. Can I stop taking Dyronib when I feel better?
A1. No. You should only stop or change the dose under the guidance of your doctor, because stopping may allow the cancer to progress.

Q2. Can I drink alcohol while taking Dyronib?
A2. There is no direct contraindication cited for moderate alcohol use, but alcohol may worsen side effects (like liver burden or fatigue). It’s best to discuss with your doctor.

Q3. What if I become pregnant while on this medicine?
A3. You must inform your healthcare provider immediately. Dasatinib may harm the unborn baby, so effective contraception is required during treatment and for a time after stopping.

Q4. How long will it take to see the benefit from this medicine?
A4. It varies by patient and can Ofer types. Some effects (like improved blood counts) may show in weeks to months, but full benefit may take longer. Regular monitoring is essential.

Q5. Are there special storage instructions?
A5. Yes. Store the tablets in a cool, dry place below 25 °C (or as per manufacturer’s instructions), out of reach of children and away from moisture/light.

Interactions Of Dyronib Tablet

There are many possible drug interactions. Notable ones include:

• Grapefruit/grapefruit juice significantly increases dasatinib levels, which may lead to increased side effects.

• Many medications (over 800) can interact with dasatinib; some increase the risk of bleeding, others change heart rhythm, or affect drug levels. Antacids, acid reducers, PPIs/H2 blockers taken close to dasatinib may reduce its absorption and effectiveness.

• Taking NSAIDs, blood thinners, or antiplatelet drugs increases bleeding risk.