Mifepro Tablet (Mifepristone) | Used for Medical Abortion of Early Pregnancy

Precaution

1. Use Only as Prescribed

Take Mifepro exactly as directed by a qualified healthcare professional. Do not change the dose, timing, or treatment schedule yourself.

2. Confirm the Pregnancy Location

An ectopic pregnancy must be ruled out before treatment. Mifepristone does not terminate an ectopic pregnancy, which can become a medical emergency if untreated.

3. Confirm the Pregnancy Duration

The appropriate regimen depends on gestational age. The FDA-approved regimen for mifepristone with Misoprostol is for an intrauterine pregnancy through 70 days of gestation.

4. Follow the Prescribed Misoprostol Schedule

Mifepristone is used as part of a regimen with Misoprostol. Do not take Misoprostol earlier, later, or in a different amount unless instructed by your healthcare professional.

5. Intrauterine Device

Tell your healthcare professional if you have an IUD. An IUD in place requires appropriate medical management before using the specific mifepristone regimen for pregnancy termination.

6. Bleeding Disorders

Inform your doctor if you have a bleeding disorder. Significant bleeding can occur during medical abortion and may require medical treatment.

7. Blood-Thinning Medicines

Tell your doctor if you take anticoagulants or other medicines that affect blood clotting, as these may increase bleeding-related concerns.

Usage 

• Take Mifepro Tablet exactly as prescribed by your healthcare professional.
• Mifepro 200 mg is used as part of a regimen with Misoprostol.
• The FDA-approved regimen uses 200 mg of Mifepristone on Day 1, followed 24–48 hours later by 800 mcg of buccal Misoprostol.
• Follow the exact instructions provided for the specific treatment you have been prescribed.
• Do not change the interval between Mifepristone and Misoprostol without medical advice.
• Vaginal bleeding and abdominal cramping may occur after treatment.
• Use sanitary pads initially if advised so that bleeding can be monitored.

Uses

1. Medical Termination of Early Intrauterine Pregnancy

Mifepro 200 mg is used with Misoprostol for medical termination of an early intrauterine pregnancy within the approved gestational-age range.

2. Progesterone Blockade

Mifepristone blocks progesterone activity, which is necessary for the pregnancy to continue.

3. Preparation for Misoprostol

Mifepristone helps prepare the uterus for the subsequent action of Misoprostol, which causes uterine contractions and helps expel pregnancy tissue.

4. Medication-Based Pregnancy Termination

Mifepristone forms part of a nonsurgical medication regimen when medical termination is clinically appropriate.

Side Effects

Common Side Effects

• Nausea
• Vomiting
• Diarrhea
• Headache
• Dizziness
• Weakness
• Abdominal cramping

Serious Side Effects

Seek urgent medical attention for:

• Prolonged or very heavy vaginal bleeding
• Severe or persistent abdominal pain
• Fainting or severe weakness
• Persistent fever
• Severe pelvic pain
• Foul-smelling vaginal discharge
• Symptoms of serious infection

FAQs

1. What is Mifepro Tablet used for?

Mifepro 200 mg contains Mifepristone and is used with Misoprostol for medical termination of an early intrauterine pregnancy within the approved gestational-age range.

2. How does Mifepro Tablet work?

Mifepristone blocks progesterone, a hormone needed to maintain pregnancy. This helps stop the pregnancy from continuing and prepares the uterus for the action of Misoprostol.

3. Is Mifepro used alone?

For the FDA-approved medical-abortion regimen, Mifepristone is used together with Misoprostol. The prescribed regimen should be followed exactly.

4. Does Mifepro cause bleeding?

Vaginal bleeding can occur during the treatment process, particularly after the Misoprostol component of the regimen. Very heavy or prolonged bleeding requires medical assessment.

5. Can Mifepro treat ectopic pregnancy?

No. Mifepristone does not treat ectopic pregnancy. An ectopic pregnancy should be ruled out before treatment.

6. Is follow-up necessary after taking Mifepro?

Yes. Follow-up is needed to confirm that the pregnancy has been completely terminated.

7. What are the common side effects of Mifepro?

Common effects include nausea, vomiting, diarrhea, headache, dizziness, weakness, fever, chills, abdominal cramping, and vaginal bleeding.

Interactions

1. Corticosteroid Medicines

Mifepristone can antagonize glucocorticoid activity. Tell your healthcare professional if you use corticosteroids, particularly long-term or for a serious medical condition.

2. Rifampin

Rifampin is a CYP3A4 inducer and can lower mifepristone exposure. Tell your doctor if you are taking rifampin.

3. Certain Anticonvulsants

Medicines such as phenytoin, phenobarbital, and carbamazepine can induce CYP3A4 and may reduce mifepristone exposure.

4. Dexamethasone

Dexamethasone can induce CYP3A4 and may reduce mifepristone exposure. Your doctor should review its use before treatment.

5. St. John's Wort

St. John's Wort can induce CYP3A4 and may reduce mifepristone concentrations. Inform your healthcare professional if you use this herbal product.

6. Ketoconazole

Ketoconazole can inhibit CYP3A4 and may increase mifepristone exposure. Tell your doctor if you are taking it or have recently taken it.

7. Itraconazole

Itraconazole is another CYP3A4 inhibitor that may increase mifepristone exposure. Medical review may be required before concurrent use.