Prograf Capsule (Tacrolimus) | For Liver Transplant and Organ Rejection Prevention

Precaution

Regular Monitoring

Prograf Capsule requires regular monitoring of tacrolimus levels. Tests may also be used to check kidney function, blood glucose, blood pressure, and electrolyte levels.

Kidney Function

Tacrolimus can affect kidney function in some people. Regular kidney-related tests are important during treatment, especially when other medicines may also affect the kidneys.

Blood Sugar

Prograf may increase blood glucose levels in some people. Regular blood sugar monitoring may be recommended during treatment.

Blood Pressure

Tacrolimus may cause an increase in blood pressure. Regular blood pressure checks can help identify changes early.

Infection Precaution

Prograf reduces certain immune system activity, which can increase the risk of infections. Inform a healthcare professional if you develop persistent fever or other unusual signs of infection.

Avoid Grapefruit

Avoid grapefruit and grapefruit juice while taking Prograf Capsule because they can increase tacrolimus levels in the body.

Avoid Live Vaccines

Live vaccines should generally be avoided while using Prograf because the medicine affects immune system activity. Discuss vaccination needs with a healthcare professional.

Usage

Take Prograf as Directed

Take Prograf Capsule exactly as advised and follow the same schedule each day. Do not change the amount or timing on your own.

Take It at the Same Time

Prograf is generally taken at consistent 12-hour intervals. Taking it at the same times each day helps maintain steady tacrolimus levels.

With or Without Food

Prograf Capsule can be taken with or without food. However, keep the method consistent every day because food can affect how much tacrolimus enters the body.

Swallow the Capsule Whole

Swallow the capsule as directed. Do not open or crush Prograf capsules.

Avoid Grapefruit

Avoid grapefruit and grapefruit juice while using Prograf because they can affect tacrolimus levels in the body.

Do Not Change the Product

Different tacrolimus formulations are not always interchangeable. If the appearance, strength, or product changes, confirm the instructions before taking it.

Regular Monitoring

Regular blood tests and health checks are important during Prograf treatment to monitor tacrolimus levels and overall health.

Uses

Prevents Organ Rejection

Prograf Capsule is used as part of transplant care to help prevent the body from rejecting a transplanted organ.

Kidney Transplant

It is used after a kidney transplant to help maintain the transplanted organ and reduce the risk of rejection.

Liver Transplant

Prograf Capsule is used following a liver transplant as part of treatment to help prevent organ rejection.

Heart Transplant

It can be used after a heart transplant to help reduce the body's immune response against the transplanted heart.

Lung Transplant

Prograf is also indicated for transplant care following a lung transplant, in combination with other medicines used for immune control.

Supports Long-Term Transplant Care

Prograf Capsule may be continued as part of ongoing transplant care, with regular monitoring to help maintain appropriate tacrolimus levels.

Side Effects

Tremors

Prograf Capsule may cause shaking or tremors in some people, particularly during ongoing treatment.

Headache

Headache can occur as a common side effect and may vary in intensity.

Diarrhea

Some people may experience loose or frequent stools while taking Prograf Capsule.

Nausea

Prograf may cause nausea or stomach discomfort, especially in some people during treatment.

High Blood Pressure

An increase in blood pressure can occur, so regular blood pressure checks may be recommended.

Changes in Kidney Function

Prograf can affect kidney function, making regular kidney-related health checks important.

Changes in Blood Sugar

Tacrolimus may increase blood sugar levels in some people, so monitoring may be needed.

Sleep Problems

Difficulty sleeping or changes in normal sleep patterns may occur during treatment.

Swelling

Some people may notice swelling, particularly around the hands, ankles, or legs.

FAQs

What is Prograf Capsule?

Prograf Capsule contains tacrolimus and helps prevent organ rejection after transplantation.

What is Prograf Capsule used for?

It is used as part of transplant care for kidney, liver, heart, or lung transplants.

How does Prograf Capsule work?

It reduces certain immune system responses that may affect a transplanted organ.

How should Prograf Capsule be taken?

Take it consistently as directed, with or without food, according to the recommended treatment plan.

Does Prograf Capsule require monitoring?

Yes. Regular tacrolimus blood-level monitoring and other health checks are generally required.

Can grapefruit be taken with Prograf Capsule?

Grapefruit and grapefruit juice should be avoided because they can affect tacrolimus levels.

Can Prograf Capsule be stopped suddenly?

Do not stop or change the dose without guidance, as consistent treatment is important for transplant care.

Interactions

Prograf Capsule contains tacrolimus, which can interact with certain medicines, foods, and supplements. These interactions may increase or decrease tacrolimus levels, so regular monitoring is important.

Grapefruit and Grapefruit Juice

Avoid grapefruit and grapefruit juice while taking Prograf Capsule. They can increase tacrolimus levels and may raise the risk of unwanted effects.

Antifungal Medicines

Some antifungal medicines, including voriconazole, posaconazole, itraconazole, ketoconazole, and fluconazole, can increase tacrolimus levels. Close monitoring may be needed when these medicines are started or stopped.

Certain Antibiotics

Antibiotics such as clarithromycin and erythromycin may increase tacrolimus levels. Inform your healthcare professional before starting an antibiotic during Prograf treatment.

Anti-Seizure Medicines

Medicines such as phenytoin, carbamazepine, and phenobarbital may reduce tacrolimus levels. This can affect the intended effect of treatment.

Blood Pressure Medicines

Some medicines used for blood pressure, including verapamil, diltiazem, nifedipine, and nicardipine, may increase tacrolimus levels and require monitoring.