Azoran Tablet (Azathioprine)
Buy Azoran Tablet (Azathioprine), Azathioprine is a widely used immunosuppressive medication that comes in tablet form. It is marketed under the brand names Azoran and Imuran. This medication plays a crucial role in various medical conditions by suppressing the immune system's activity.
Azoran Tablet (Azathioprine): A Comprehensive Guide
Azathioprine is a widely used immunosuppressive medication that comes in tablet form. It is marketed under the brand names Azoran and Imuran. This medication plays a crucial role in various medical conditions by suppressing the immune system's activity. Azathioprine is an immunosuppressive medication that functions by inhibiting the synthesis of DNA and RNA in rapidly dividing cells, particularly immune cells. This property makes it valuable in various medical scenarios, including organ transplantation and autoimmune diseases. As a prodrug, Azathioprine is converted into its active form, 6-mercaptopurine, within the body. This active metabolite interferes with the proliferation of immune cells by disrupting their genetic material, thereby suppressing the immune system's activity. By targeting the rapid division of immune cells that underlies inflammation and immune responses, Azathioprine helps manage conditions where excessive or misdirected immune activity plays a role. It is frequently used to prevent organ rejection after transplantation and to treat autoimmune disorders such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus. However, due to its impact on the immune system, Azathioprine use requires careful monitoring and management to balance its benefits with potential side effects and risks.
Azathioprine Dosage Information:
Initial Dose: The typical starting dose for Azathioprine tablets is often weight-based and can range from 1 to 3 mg per kilogram of body weight. This dose is usually divided into 1 to 4 doses per day.
Maintenance Dose: After the initial dose, the maintenance dose is usually lower and falls within the range of 1 to 2 mg per kilogram of body weight, divided into several daily doses.
Dosage Adjustment: Dosage adjustments might be necessary based on the patient's response, overall health, and any potential adverse effects. Regular monitoring is crucial to find the optimal dosage.
Duration of Treatment: Azathioprine is often prescribed for the long term. The duration of treatment can vary depending on the underlying condition and the patient's response to the medication.
Dosage Forms: Azathioprine tablets are available in various strengths, such as 25 mg and 50 mg, allowing for flexibility in dosing adjustments.
Missed Dose and Overdose:
Missed Dose: If a dose is missed, it's important to take it as soon as remembered. However, if it's close to the time for the next scheduled dose, it's advisable to skip the missed dose and continue with the regular dosing schedule.
Overdose: Overdosing on Azathioprine can lead to severe adverse effects. Symptoms of overdose might include nausea, vomiting, diarrhea, reduced blood cell counts, and increased susceptibility to infections. In case of a suspected overdose, medical attention should be sought immediately.
Alternatives to Azathioprine Tablet
In cases where Azathioprine tablets (marketed as Azoran and Imuran) are not suitable or well-tolerated, several alternative medications can be considered depending on the specific medical condition and individual patient factors. For immune suppression in organ transplant recipients, alternatives like mycophenolate mofetil or tacrolimus may be used. In the management of autoimmune diseases such as rheumatoid arthritis, biological medications like adalimumab or methotrexate might offer viable alternatives. Additionally, corticosteroids can be employed to control inflammation in certain conditions, although their long-term use may have its own set of side effects. It's essential for healthcare providers to assess each patient's medical history, disease severity, and potential contraindications to determine the most appropriate alternative to Azathioprine tablets.
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Some of the precautionary measures to be taken while using Azoran Tablet (Azathioprine)
- Pregnancy and Breastfeeding: Azathioprine/Imuran is generally not recommended during pregnancy and breastfeeding due to potential risks to the fetus or infant. Consultation with a healthcare provider is crucial in such situations.
- Allergic Reactions: Individuals with known hypersensitivity to Azathioprine should avoid its use.
- Drug Allergies: Patients should inform their healthcare provider about any allergies to medications, as well as their medical history, before starting Azathioprine.
- Vaccinations: Live vaccines should be avoided during Azathioprine treatment due to the weakened immune response. Inactivated vaccines are generally safe but should be discussed with a healthcare provider.
- Malignancy Risk: Prolonged immunosuppression might slightly increase the risk of developing certain malignancies. Regular cancer screenings are advisable.
Some of the specific indications for Imuran/Azoran Tablet (Azathioprine) include
- Organ Transplants: Azathioprine plays a crucial role in preventing Anti Rejection in recipients of kidney, liver, and heart transplants.
- Autoimmune Diseases: It is prescribed for various autoimmune conditions like Rheumatoid Arthritis, systemic lupus erythematosus, and inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
- Dermatological Conditions: Azathioprine can also be used to treat certain severe skin disorders, including pemphigus vulgaris and dermatomyositis.
- Rheumatic Disorders: It is indicated for specific rheumatic diseases like polymyositis and vasculitis.
- Off-label Uses: In some cases, Azathioprine might be used off-label for conditions not mentioned in its official indications, based on the healthcare provider's assessment.
Azathioprine Tablet cost:
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Crucial Side Effects to Be Observed When Using Azoran Tablet (Azathioprine)
- Gastrointestinal: Common side effects include nausea, vomiting, and diarrhea. These symptoms can often be managed by taking the medication with food.
- Bone Marrow Suppression: Azathioprine can suppress bone marrow function, leading to reduced production of blood cells. This might increase the risk of infections, anemia, and bleeding.
- Liver Function: Regular monitoring of liver function is essential, as Azathioprine can affect liver enzymes and potentially lead to liver damage.
- Skin Reactions: Some patients might experience skin rashes or photosensitivity reactions when exposed to sunlight.
- Increased Infection Risk: Immune system suppression increases the susceptibility to infections. Patients should be cautious around individuals with contagious illnesses.
Frequently Asked Queries About Azathioprine Tablet
Q1. Can Azathioprine be taken on an empty stomach?
Azathioprine is generally recommended to be taken with food to help reduce gastrointestinal side effects like nausea and vomiting. Taking it with a meal can also aid in its absorption, ensuring better efficacy.
Q2. Are there any specific monitoring requirements during Azathioprine treatment?
Yes, regular blood tests are necessary to monitor blood cell counts, liver function, and overall health. This helps healthcare providers make informed decisions about dosage adjustments and identify any potential adverse effects early on.
Q3. Can Azathioprine be abruptly stopped if I start feeling better?
No, sudden discontinuation of Azathioprine can lead to disease flare-ups and increased risks of organ rejection or disease progression. Any changes to the medication regimen should be discussed with a healthcare provider to ensure a safe transition.
Q4. Can I engage in outdoor activities while taking Azathioprine?
Yes, but it's important to practice sun protection methods like using sunscreen, wearing protective clothing, and avoiding prolonged sun exposure. Azathioprine can increase sensitivity to sunlight, leading to skin reactions upon exposure.
Q5. Can Azathioprine affect fertility or reproductive health?
Azathioprine's impact on fertility is not fully understood, but it's advisable to discuss any concerns with a healthcare provider. Pregnant individuals and those planning pregnancy should work closely with their doctor to assess the benefits and risks of Azathioprine use.
Significant Drug Interactions that Require Attention For Azoran Tablet (Azathioprine)
- Allopurinol: Concurrent use of Azathioprine and allopurinol (a medication used for gout) can lead to an increased risk of bone marrow suppression. Dosage adjustments might be necessary.
- Warfarin: Azathioprine can affect the metabolism of warfarin, an anticoagulant, potentially leading to altered blood clotting. Close monitoring of blood clotting parameters is essential.
- ACE Inhibitors: The combination of Azathioprine with ACE inhibitors, used for hypertension, might increase the risk of blood cell disorders.
- Vaccines: As mentioned earlier, the use of live vaccines is contraindicated during Azathioprine treatment due to the potential for an inadequate immune response.
- Other Immunosuppressants: Combining Azathioprine with other immunosuppressive medications might increase the risk of infections and other adverse effects. Such combinations should be managed carefully by healthcare providers.
| Manufacturer | : | RPG Life Science, India |
| Equivalent Brand | : | Imuran |
| Generic Search | : | Azathioprine |
