GMH HP Injection (Menotrophin): Human Menopausal Gonadotropin Fertility Injection | for ovarian stimulation, ovulation induction and improvement of sperm production in infertility care
Product Overview
GMH HP Injection is an injectable hormonal formulation containing Menotrophin, also known as human menopausal gonadotrophin (hMG), used in fertility treatment to stimulate the development of ovarian follicles in women and support sperm production in certain men. It contains gonadotrophic hormones with follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.
The formulation works by providing gonadotrophin activity that promotes follicular development and ovarian stimulation. In men, menotrophin may be used alongside other hormonal therapy to support spermatogenesis when clinically appropriate. Its use generally requires careful medical supervision and monitoring of treatment response.
Pharmacological Profile
| Parameter | Details |
| Active Ingredient | Menotrophin |
| Drug Class | Gonadotrophin / Human Menopausal Gonadotrophin (hMG) |
| Dosage Form | Injection |
| Hormonal Activity | FSH and LH activity |
| Primary Target | Ovaries and reproductive system |
| Therapeutic Area | Fertility and reproductive health |
Mechanism Insights (How It Works)
- Follicular Stimulation
Menotrophin provides FSH activity that stimulates the growth and development of ovarian follicles, supporting the maturation of eggs during fertility treatment. - Ovarian Hormonal Support
The LH activity of menotrophin contributes to ovarian steroidogenesis and supports the hormonal environment required for follicular development. - Support for Ovulation
As follicles mature, treatment may be incorporated into fertility protocols designed to promote ovulation, often with additional hormonal medicines according to the prescribed treatment plan. - Support for Spermatogenesis
In selected male infertility cases, menotrophin may be administered with appropriate hormonal therapy to stimulate the testes and support sperm production.
Administration Guidelines
- Administer only by the route and dosage prescribed by a qualified healthcare professional
- The injection should be prepared and administered according to the product instructions
- Do not change the dose or treatment schedule without medical advice
- Women receiving ovarian stimulation generally require clinical and ultrasound monitoring
- Follow the complete fertility-treatment protocol as prescribed
Clinical Considerations
- Commonly used as part of medically supervised fertility-treatment protocols
- In women, treatment may help stimulate the development of multiple ovarian follicles
- In men, it may be considered for selected cases of hypogonadotropic hypogonadism to support sperm production
- Treatment response should be monitored to reduce the risk of excessive ovarian stimulation
- Dosage and treatment duration vary according to the individual's condition and fertility-treatment plan
- Use should remain under specialist supervision because gonadotrophin therapy can cause significant hormonal and reproductive effects
Precautions:
GMH HP Injection (Menotrophin) should be used under the supervision of a qualified healthcare professional to ensure safe and effective treatment. Appropriate monitoring is important, particularly in women undergoing fertility treatment or those with underlying medical conditions.
General Precautions
- Use only as prescribed by a fertility specialist or healthcare professional
- Do not change the dose or treatment schedule without medical advice
- Regular monitoring through ultrasound and hormone tests may be required
- Inform your doctor about all medicines, supplements, and fertility treatments being used
- Do not self-administer unless proper injection instructions have been provided
- Treatment should be discontinued and medical attention sought if severe abdominal pain, swelling, or breathing difficulties occur
Ovarian Hyperstimulation Considerations
- Menotrophin may increase the risk of ovarian hyperstimulation syndrome (OHSS)
- Patients should be monitored for excessive ovarian response during treatment
- Report severe abdominal pain, rapid weight gain, nausea, vomiting, or difficulty breathing promptly
- Follow the recommended monitoring schedule throughout treatment
Further doses may need to be adjusted or withheld based on ovarian response
Pregnancy & Breastfeeding
- GMH HP Injection is generally used to stimulate ovulation before pregnancy and should not be continued after pregnancy is confirmed unless specifically advised
- Inform your doctor immediately if pregnancy occurs during treatment
- Consult a healthcare professional before using the medicine while breastfeeding
- Treatment should be planned according to individual fertility and pregnancy requirements
Medical Conditions
- Inform your doctor if you have a history of ovarian cysts, unexplained vaginal bleeding, thyroid or adrenal disorders
- Use cautiously in patients with conditions that may be affected by hormonal stimulation
- Tell your doctor about any history of blood-clotting problems or conditions that increase the risk of thrombosis
- Regular medical assessment may be required throughout treatment
Injection & Monitoring Precautions
- GMH HP Injection should be administered using the recommended injection technique
- Do not use the injection if the solution appears abnormal or the packaging is damaged
- Store the medicine according to the manufacturer's instructions
- Keep all scheduled ultrasound and hormonal monitoring appointments
- Seek immediate medical attention for severe pelvic pain, significant abdominal swelling, chest pain, or difficulty breathing
Usage
General Usage Information
GMH HP Injection (Menotrophin) is used as part of fertility treatment to stimulate the ovaries and support the development of ovarian follicles. In men, it may be prescribed to stimulate sperm production in certain cases of hormonal infertility. The treatment should be administered under the supervision of a qualified healthcare professional, with dosage and duration tailored to the individual’s treatment plan.
Key Usage Points
✔ Use the injection exactly as prescribed by a healthcare professional
✔ Administer only by the recommended injection route
✔ Treatment may require regular ultrasound or hormone monitoring
✔ Do not change the dose or treatment schedule without medical advice
✔ Follow the complete fertility-treatment plan for the best possible outcome
Uses
GMH HP Injection is commonly used in fertility treatment to stimulate follicular development and ovulation in women. It may also be prescribed for certain cases of male infertility to stimulate sperm production when related to hormonal deficiencies.
How to Use
- Administer the injection only as directed by a healthcare professional
- The injection is generally given by subcutaneous or intramuscular
- The dose and duration depend on the patient's age, medical condition, hormone levels, and treatment response
- Regular monitoring may be required during treatment to assess follicular development and hormone levels
- Regular monitoring may be required during treatment to assess follicular development and hormone levels
- Follow the prescribed schedule carefully and do not take additional doses if one is missed without consulting your healthcare provider
Side Effects
General Safety Information
GMH HP Injection (Menotrophin) may cause side effects, particularly during fertility treatment. Most side effects are mild and temporary, but the severity can vary depending on the individual’s response to treatment and dosage. It should be used under the supervision of a qualified healthcare professional.
Common Side Effects
✔ Headache
✔ Abdominal pain or discomfort
✔ Nausea or vomiting
✔ Injection-site pain, redness, or swelling
✔ Bloating
✔ Breast tenderness
✔ Mood changes
These effects are generally mild and may improve as the body adjusts to treatment. Inform your healthcare provider if they persist or become bothersome.
Serious Side Effects (Rare but Important)
⚠ Seek immediate medical attention if you experience:
- Severe abdominal or pelvic pain
- Significant abdominal swelling or rapid weight gain
- Difficulty breathing
- Severe nausea or persistent vomiting
- Reduced urine output
- Sudden swelling of the hands or legs
- Signs of a severe allergic reaction, such as rash, facial swelling, or difficulty breathing
These symptoms may indicate ovarian hyperstimulation syndrome (OHSS) or another serious reaction requiring prompt medical evaluation.
Risk Factors & Monitoring
- Women receiving fertility treatment may require regular monitoring of ovarian response.
- The risk of OHSS may be higher in patients who develop multiple ovarian follicles or have certain fertility-related conditions.
- Ultrasound examinations and hormone tests may be recommended during treatment.
- Patients should follow the prescribed dose and schedule carefully and should not self-administer additional doses.
FAQs
What is GMH HP Injection (Menotrophin) used for?
GMH HP Injection contains Menotrophin and is used in fertility treatment to stimulate the ovaries in women and support sperm production in men. It is generally given under specialist medical supervision.
How does GMH HP Injection work in the body?
Menotrophin contains follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. In women, it helps stimulate ovarian follicles and egg development. In men, it can support sperm production when hormonal stimulation is required.
Can GMH HP Injection be used during pregnancy?
GMH HP Injection is generally not used during pregnancy. It is intended for fertility treatment before pregnancy occurs and should only be used according to a fertility specialist's instructions.
How should GMH HP Injection be administered?
GMH HP Injection is usually given by injection under the supervision or instruction of a healthcare professional. The dose and treatment schedule depend on the individual's fertility condition and response to treatment.
Interactions
| Manufacturer | : | Gufic Biosciences Ltd |
| Equivalent Brand | : | Menopur |
| Generic Search | : | Menotrophin |












