Introduction to Dolutegravir Tablet (Instgra)

Dolutegravir, marketed under the brand name Instgra, is an antiretroviral medication used in the treatment of Human Immunodeficiency Virus (HIV) infection. It belongs to the integrase strand transfer inhibitor (INSTI) class of drugs and has shown exceptional efficacy in managing HIV-1 infection in both treatment-naive and treatment-experienced individuals. Dolutegravir works by inhibiting the viral integrase enzyme, which prevents the integration of viral DNA into the host cell's genome. This mechanism of action disrupts the viral replication cycle, reducing the viral load and preserving the immune system, thus slowing down the progression of the disease and improving the overall quality of life for HIV patients.

Dosage Information

Dolutegravir tablets are available in various strengths, typically 50mg and 100mg, and the prescribed dosage can vary depending on the patient's age, weight, renal function, and other individual factors. It is essential to follow the healthcare provider's instructions and the information provided on the prescription label. Generally, Dolutegravir is taken once daily, with or without food. It is crucial to take the medication consistently at the same time each day to maintain steady levels of the drug in the body and achieve optimal treatment outcomes.

For adult patients, the recommended dose of Dolutegravir is usually 50mg once daily. For individuals with certain drug-resistance mutations or other specific treatment needs, a higher dose of 100mg may be prescribed. Pediatric dosing varies based on the child's weight, and healthcare providers determine the appropriate dose for children living with HIV.

Tivicay is the brand name for the drug Dolutegravir. It is an essential antiretroviral medication used to treat HIV-1 infection. Tivicay belongs to the integrase strand transfer inhibitor (INSTI) class, which effectively inhibits the integrase enzyme, thereby blocking viral replication in the body. It is a potent and well-tolerated drug that has become a cornerstone in HIV treatment, providing patients with a chance at a healthier and longer life. At 1mgstore.com, we offer Tivicay (dolutegravir Tablet) at the best price, making it more accessible to those in need of this life-saving medication.

Dolutegravir Tablet Best Price at 1mgstore.com

At 1mgstore.com, we take pride in offering Dolutegravir Tablets at the best price to our valued customers. We understand the importance of affordable and accessible healthcare, especially for those managing chronic conditions like HIV. Our commitment to providing competitive prices ensures that patients can obtain the necessary medications without undue financial burden. You can trust 1mgstore.com to provide genuine and cost-effective Dolutegravir Tablets, allowing you to focus on your health and well-being with confidence. we have Dolutegravir Tablets for sale, offering you a convenient way to access this critical HIV treatment. We prioritize the authenticity and quality of our medications, sourcing them from reputable manufacturers and suppliers.

Some important Safety Advice to be taken while using Instgra Tablet (Dolutegravir)

While Dolutegravir Tablet (Instgra) is a life-saving drug that plays a crucial role in managing HIV-1 infection, it is essential to exercise caution and adhere to certain precautions to ensure its safe and effective use:

Medical History: Before starting Dolutegravir/Tivicay treatment, patients should provide their healthcare providers with a comprehensive medical history, including any existing medical conditions, allergies, or previous adverse drug reactions. Special consideration should be given to liver, kidney, and bone health conditions.
Pregnancy and Breastfeeding: Pregnant or breastfeeding individuals should consult their healthcare providers before using Dolutegravir. Although this medication is valuable in preventing mother-to-child transmission of HIV, its use during pregnancy requires careful evaluation of potential risks and benefits.
Pediatric Use: Dolutegravir may be prescribed for children living with HIV, but the dosage should be determined based on the child's weight and age. Pediatric patients should be closely monitored during treatment.
Geriatric Use: Elderly patients may require dose adjustments based on their age-related physiological changes and any concomitant medical conditions. Close monitoring is necessary for this population.
Bone Health: Long-term use of Dolutegravir has been associated with some effects on bone mineral density. Patients with a history of bone issues or those at risk for osteoporosis should be closely monitored, and supplemental calcium and vitamin D may be considered.
Hypersensitivity Reactions: If any signs of hypersensitivity reactions, such as rash, fever, or systemic symptoms, occur during Dolutegravir treatment, medical attention should be sought immediately.
Liver Function: Patients with liver impairment or pre-existing liver conditions may require dosage adjustments or closer monitoring during treatment with Dolutegravir.
Renal Function: Dolutegravir is primarily eliminated through the kidneys. Patients with impaired renal function may require dose adjustments based on their creatinine clearance levels.
Co-Infections: Patients with HIV may also have other co-existing infections, such as Hepatitis B or C. Dolutegravir's potential interactions with medications used to treat these co-infections should be considered.
Concomitant Medications: Inform your healthcare provider about all medications, including over-the-counter drugs and herbal supplements, you are taking. Dolutegravir may interact with certain medications, affecting their effectiveness or causing adverse reactions.

Application of Dolutegravir Tablet (Instgra)

First-line Treatment for HIV: Dolutegravir is commonly used as a first-line therapy for HIV-1 infection in both adults and children due to its potent antiviral activity and favorable safety profile. It is often combined with other antiretroviral drugs to form highly active antiretroviral therapy (HAART) regimens. These combinations can effectively suppress viral replication, decrease the viral load, and increase CD4 cell counts, helping patients maintain a healthier immune system.
Treatment-Experienced Patients: Dolutegravir/Tivicay is also valuable for individuals who have previously received antiretroviral therapy and have developed resistance to other drug classes. As an integrase inhibitor, it offers an alternative mechanism of action and can be effective in suppressing the virus in those with resistant strains.
Prevention of Mother-to-Child Transmission: Dolutegravir plays a crucial role in preventing mother-to-child transmission of HIV. Pregnant women living with HIV are often prescribed this medication to reduce the risk of passing the virus to their unborn child.
Pre-Exposure Prophylaxis (PrEP): In some cases, Dolutegravir may be used as part of a PrEP regimen to prevent HIV infection in individuals at high risk of acquiring the virus. It is typically combined with other antiretroviral drugs and should be taken consistently to provide effective protection.
HIV Post-Exposure Prophylaxis (PEP): Dolutegravir, when used in combination with other antiretroviral medications, is employed as PEP to reduce the risk of HIV transmission after potential exposure to the virus. Prompt initiation of PEP within a specified timeframe after exposure is crucial for its effectiveness.

Order Dolutegravir Tablet at 1mgstore.com

Ordering Dolutegravir Tablets at 1mgstore.com is a simple and hassle-free process. Our user-friendly website allows you to browse through our extensive range of medications, add the required products to your cart, and proceed to the checkout with ease. We have a secure and efficient payment system in place to safeguard your personal information and ensure a smooth transaction. Once you place your order, our dedicated team works diligently to dispatch the package promptly, ensuring that you receive your medication at your doorstep in the shortest possible time.

Some of the secondary effects of Instgra Tablet (Dolutegravir)

Headache:Mild to moderate headaches may occur during the initial stages of treatment.
Nausea and Diarrhea: Gastrointestinal disturbances, such as nausea, vomiting, and diarrhea, may be experienced by some patients.
Fatigue: Dolutegravir/Tivicay can cause mild fatigue or tiredness.
Insomnia: Difficulty falling asleep or staying asleep may be reported by some individuals.
Rash: Skin rash may occur in some cases, which should be promptly reported to a healthcare professional.
Dizziness: Some patients may experience dizziness or lightheadedness.
Elevated Liver Enzymes: In rare cases, Dolutegravir can cause temporary elevations in liver enzymes.
Depression or Mood Changes: Some individuals may experience changes in mood or depressive symptoms.

Answers to Common Inquiries About Instgra Tablet (Dolutegravir)

FAQ: Can I take Dolutegravir with other HIV medications?

Answer: Yes, Dolutegravir can be taken with other HIV medications. It is often prescribed as part of combination therapy to enhance treatment efficacy and reduce the risk of drug resistance. However, informing your healthcare provider about all the medications you are taking is essential to avoid potential drug interactions.

FAQ: Does Dolutegravir/Tivicay cure HIV?

Answer: Dolutegravir is a potent antiretroviral medication that effectively manages HIV-1 infection, reducing the viral load and preserving the immune system. However, it is crucial to note that Dolutegravir is not a cure for HIV. It is a life-long treatment that helps control the virus and improves the patient's quality of life.

FAQ: Can Dolutegravir be taken during pregnancy?

Answer: Dolutegravir can be used during pregnancy, but it requires careful consideration. Pregnant individuals with HIV should consult their healthcare providers to assess the potential risks and benefits. In some cases, alternative medications may be recommended during certain stages of pregnancy to minimize potential adverse effects on the developing fetus.

FAQ: Are there any food restrictions while taking Dolutegravir?

Answer: Dolutegravir can be taken with or without food, offering flexibility in its administration. There are no specific food restrictions associated with Dolutegravir. However, taking it consistently at the same time daily, either with or without food, is essential for maintaining steady drug levels in the body and maximizing treatment efficacy.

FAQ: Can Dolutegravir prevent HIV transmission?

Answer: Dolutegravir is primarily used for the treatment of existing HIV infection and the prevention of mother-to-child transmission during pregnancy. While it is not prescribed as pre-exposure prophylaxis (PrEP) for HIV-negative individuals, it can significantly reduce the risk of HIV transmission to the newborn when administered to the mother during pregnancy and breastfeeding. For HIV prevention in high-risk individuals, other medications specifically approved for PrEP are recommended.

Instgra Tablet (Dolutegravir) can interact with other medications

Antacids: Avoid taking Dolutegravir simultaneously with antacids that contain aluminum or magnesium, as they may decrease the absorption of the drug.
Anticonvulsants: Some anticonvulsants, such as phenytoin and carbamazepine, may reduce Dolutegravir levels, potentially reducing its effectiveness.
HIV Protease Inhibitors: Certain HIV protease inhibitors may interact with Dolutegravir, requiring dose adjustments or alternative treatments.
Rifampin: Rifampin, an antibiotic, may reduce Dolutegravir/Tivicay levels and should be used with caution or avoided altogether.
Metformin: Dolutegravir may increase metformin levels in the body, necessitating close monitoring for potential side effects.
Warfarin: Patients on warfarin should have their international normalized ratio (INR) closely monitored, as Dolutegravir can influence warfarin metabolism.
Other Medications: Dolutegravir may interact with a wide range of medications, including antivirals, antibiotics, and certain cardiovascular drugs. Always inform your healthcare provider about all the medications you are taking to avoid potential interactions.