Oestro Gel (Estradiol) | Used for Menopause Symptoms & Estrogen Deficiency

Precaution

1. Use Only as Prescribed

Use Oestro Gel exactly as directed by your healthcare professional. Do not increase the amount or apply it more frequently than prescribed.

2. Pregnancy

Oestro Gel is not intended for use during pregnancy. Inform your doctor if you become pregnant or think you may be pregnant during treatment.

3. Unexplained Vaginal Bleeding

Tell your healthcare professional about any unexplained or undiagnosed vaginal bleeding before starting treatment. Persistent or unusual bleeding after menopause requires medical evaluation.

4. History of Blood Clots

Inform your doctor if you have previously had deep-vein thrombosis, pulmonary embolism, or another blood-clotting condition. Systemic estrogen therapy can increase the risk of blood clots.

5. Watch for Blood-Clot Symptoms

Seek urgent medical attention if you develop sudden chest pain, difficulty breathing, coughing blood, or sudden pain and swelling in one leg.

6. Breast Cancer

Tell your doctor if you have current or previous breast cancer or another estrogen-dependent cancer. Estrogen therapy may not be appropriate in these conditions.

7. Liver Problems

Inform your doctor if you have liver disease or a history of significant liver problems. Estradiol gel is contraindicated in certain hepatic conditions.

Usage 

• Use Oestro Gel exactly according to your prescription.
• Apply the gel only to the recommended area of clean, dry skin.
• Follow the specific application instructions supplied with your product.
• Allow the gel to dry before covering the application area with clothing.
• Wash your hands after applying the gel unless the hands are the application area.
• Avoid washing the application area immediately after applying the gel.
• Do not apply the gel to the breasts.
• Avoid transferring the gel to another person's skin through direct contact before the application area is dry.

Uses

1. Menopausal Hot Flashes

Estradiol gel is used to reduce moderate to severe vasomotor symptoms associated with menopause, including hot flashes.

2. Night Sweats

By treating menopausal vasomotor symptoms, systemic estradiol therapy may help reduce associated night sweats in appropriate patients.

3. Menopausal Vaginal Symptoms

Estradiol gel may be used to treat moderate to severe menopausal changes affecting the vulvar and vaginal area.

4. Vaginal Dryness

Estrogen deficiency after menopause can cause vaginal dryness. Systemic estrogen therapy may help relieve this symptom when appropriate.

Side Effects

Common Side Effects

Some people may experience:

• Headache
• Breast tenderness or pain
• Nausea
• Abdominal discomfort
• Bloating
• Vaginal bleeding or spotting
• Mood changes

Serious Side Effects

Seek immediate medical attention if you experience:

• Sudden chest pain
• Difficulty breathing
• Coughing blood
• Painful swelling or redness of one leg
• Sudden severe headache
• Sudden weakness or numbness
• Sudden vision changes

FAQs

1. What is Oestro Gel used for?

Oestro Gel contains Estradiol and is used as estrogen hormone replacement therapy for certain moderate to severe symptoms associated with menopause, including hot flashes and menopausal vulvar or vaginal symptoms.

2. What is the active ingredient in Oestro Gel?

The active ingredient is Estradiol, an estrogen hormone.

3. How does Oestro Gel work?

Oestro Gel delivers estradiol through the skin. The hormone replaces some of the estrogen that declines during menopause and helps reduce certain symptoms associated with estrogen deficiency.

4. Can Oestro Gel help with hot flashes?

Yes. Estradiol gel is indicated for the treatment of moderate to severe vasomotor symptoms associated with menopause, including hot flashes.

5. Can Oestro Gel help with vaginal dryness?

Estradiol therapy can help treat moderate to severe menopausal changes affecting the vulvar and vaginal area.

6. Is Oestro Gel applied to the skin?

Yes. Oestro Gel is a transdermal preparation that is applied to the skin according to the instructions for the specific product.

7. Can Oestro Gel be used with a uterus?

Women who have a uterus and use systemic estrogen may generally require a suitable progestogen to reduce the risk of endometrial problems. Your healthcare professional should determine the appropriate regimen.

Interactions

1. CYP3A4-Inducing Medicines

Medicines that increase CYP3A4 activity can increase estrogen metabolism and may reduce estradiol levels or treatment effects.

2. CYP3A4-Inhibiting Medicines

Medicines that inhibit CYP3A4 may increase estrogen concentrations. Tell your doctor about medicines that affect this enzyme system.

3. Anticonvulsant Medicines

Some anticonvulsants, including phenytoin, phenobarbital, and carbamazepine, can increase estrogen metabolism and may reduce estrogen exposure.

4. Rifampicin

Rifampicin can increase estrogen metabolism and may reduce the effects of estradiol therapy.

5. Rifabutin

Rifabutin may also increase estrogen metabolism and can potentially alter estradiol exposure.

6. Certain HIV Medicines

Some antiretroviral medicines can affect estrogen metabolism. Tell your healthcare professional about all HIV medicines you take.

7. Nevirapine and Efavirenz

These medicines can affect CYP enzymes involved in estrogen metabolism and may change estradiol exposure.