Resihance Tablet (Regorafenib) | For Metastatic Colorectal Cancer, Gastrointestinal Stromal Tumors, and Hepatocellular Carcinoma

Precaution

Resihance Tablet contains regorafenib, a targeted therapy used to treat certain types of cancer. Following the recommended precautions and attending regular check-ups can help support safer treatment.

1. Liver Function

Resihance Tablet may affect liver function. Your healthcare professional may arrange regular liver tests and review symptoms such as yellowing of the skin or eyes, dark urine, or unusual tiredness.

2. Blood Pressure

Regorafenib may increase blood pressure. Check your blood pressure as advised and report persistent headaches, dizziness, or unusually high readings.

3. Heart Health

Inform your healthcare professional about any existing heart conditions. Seek urgent medical attention for chest pain, sudden breathlessness, or an irregular heartbeat.

4. Bleeding Risk

Resihance Tablet may increase the risk of bleeding. Inform your healthcare team about unusual bruising, bleeding, or any history of bleeding problems.

5. Wound Healing

Regorafenib may delay wound healing. Tell your specialist about planned surgery or dental procedures, as treatment may need to be adjusted.

6. Hand-Foot Skin Reactions

Redness, tenderness, peeling, or blisters may develop on the palms and soles. Report these changes early so your healthcare team can advise you.

7. Pregnancy and Breastfeeding

Regorafenib may harm an unborn baby. Inform your healthcare professional if you are pregnant, planning a pregnancy, or breastfeeding. Discuss suitable contraception and breastfeeding guidance before treatment.

Usage

Resihance Tablet contains regorafenib, a targeted therapy medicine used to treat certain cancers. It works by blocking proteins involved in cancer cell growth and the development of blood vessels that support tumours. Use it only under the guidance of your treating specialist.

1. How to Take Resihance Tablet

Swallow the tablet with water as directed by your healthcare professional. Follow the product-specific instructions about taking it with food.

2. Dosage and Treatment Schedule

The dose and treatment cycle depend on your diagnosis, overall health, and response to treatment. Do not change the dose or schedule without consulting your specialist.

3. When to Take Resihance Tablet

Take the tablet at the time and in the way recommended by your specialist. Following the same schedule each day can help maintain consistency.

4. Missed Dose

If you miss a dose, follow the instructions in the product leaflet or contact your healthcare team. Do not take an extra dose to make up for a missed one.

Uses

Resihance Tablet contains regorafenib, a targeted therapy medicine that blocks specific proteins involved in cancer cell growth and tumour development. It is used to treat certain cancers under specialist supervision.

1. Metastatic Colorectal Cancer

Resihance Tablet may be used to treat colorectal cancer that has spread to other parts of the body, particularly when previous treatments have not controlled the disease adequately.

2. Gastrointestinal Stromal Tumours (GIST)

Regorafenib is used for certain gastrointestinal stromal tumours, which develop in tissues of the digestive tract, when earlier treatments have been unsuccessful or are no longer suitable.

3. Hepatocellular Carcinoma

Resihance Tablet may be used for hepatocellular carcinoma, the most common type of primary liver cancer, in selected patients who have received previous treatment.

4. Blocking Tumour Growth Signals

Regorafenib targets specific enzymes involved in cell growth and the formation of blood vessels that supply tumours. This action helps slow disease progression in eligible patients.

Important: Resihance Tablet is not suitable for every cancer or every patient. Its use depends on the diagnosis, previous treatments, liver function, and the treating specialist’s assessment.

Side Effects

Resihance Tablet contains regorafenib, a targeted therapy medicine used to treat certain cancers. Like other medicines, it may cause side effects. Their type and severity can vary from person to person.

1. Fatigue and Weakness

Feeling tired or having less energy is common during treatment. Rest when needed and inform your healthcare team if fatigue affects daily activities.

2. Diarrhoea

Resihance Tablet may cause loose or frequent stools. Drink fluids as advised and contact your healthcare professional if diarrhoea becomes severe or persistent.

3. Hand-Foot Skin Reactions

Redness, swelling, tenderness, peeling, or blisters may develop on the palms and soles. Report these changes early to help manage discomfort.

4. High Blood Pressure

Regorafenib may increase blood pressure. Regular monitoring is important, and persistent high readings should be discussed with your healthcare professional.

5. Reduced Appetite

Some people may experience a reduced appetite or weight loss during treatment. Tell your healthcare team if eating becomes difficult or your weight changes noticeably.

6. Nausea and Vomiting

Nausea or vomiting may occur while taking Resihance Tablet. Seek advice if symptoms persist or make it difficult to keep fluids down.

7. Mouth Sores

Mouth soreness or ulcers may develop during treatment. Inform your healthcare team if discomfort affects eating, drinking, or oral care.

FAQs

1. What is Resihance Tablet used for?

Resihance Tablet contains regorafenib and is used to treat certain cancers, including metastatic colorectal cancer, gastrointestinal stromal tumours (GIST), and hepatocellular carcinoma.

2. What is the active ingredient in Resihance Tablet?

The active ingredient is regorafenib, a targeted therapy medicine that blocks specific proteins involved in tumour growth.

3. How does Resihance Tablet work?

It blocks certain enzymes involved in cancer cell growth and the formation of blood vessels that supply tumours.

4. How should Resihance Tablet be taken?

Take Resihance Tablet exactly as directed by your treating specialist. Follow the prescribed dose, schedule, and food instructions.

5. What are the common side effects of Resihance Tablet?

Common effects may include fatigue, diarrhoea, reduced appetite, high blood pressure, and hand-foot skin reactions.

6. Does Resihance Tablet affect liver function?

Yes. Regorafenib may affect the liver, so regular liver function tests are generally needed during treatment.

7. Can Resihance Tablet interact with other medicines?

Yes. Certain antibiotics, antifungal medicines, seizure-control medicines, and herbal products may affect regorafenib levels. Inform your healthcare professional about everything you take.

8. Can Resihance Tablet be used during pregnancy?

Regorafenib may harm an unborn baby. Discuss pregnancy planning and suitable contraception with your healthcare professional before treatment.

Interactions

1. Strong CYP3A4 Inducers

Medicines such as rifampicin, phenytoin, and carbamazepine may lower regorafenib levels and reduce its effectiveness. These combinations should be avoided unless your specialist advises otherwise.

2. Strong CYP3A4 Inhibitors

Medicines such as clarithromycin, ketoconazole, and itraconazole may change regorafenib levels and increase the risk of unwanted effects. Inform your healthcare professional if you take any of these medicines.

3. Herbal Products

St. John’s wort may reduce regorafenib levels and affect treatment results. Tell your healthcare team about any herbal products or supplements you use.

4. Grapefruit and Grapefruit Juice

Grapefruit products may affect how regorafenib is processed in the body. Avoid grapefruit and grapefruit juice during treatment unless your specialist confirms otherwise.

5. Blood-Thinning Medicines

Regorafenib may increase bleeding concerns when used with medicines such as warfarin. Your healthcare team may recommend closer monitoring if these medicines are used together.

6. Certain Cholesterol-Lowering Medicines

Regorafenib can increase the levels of some medicines processed through specific transport proteins, including rosuvastatin. Inform your healthcare professional if you take cholesterol-lowering medicines so they can assess the combination.

7. Other Cancer Medicines

Medicines such as irinotecan may interact with regorafenib and change drug levels in the body. Your specialist should review all cancer treatments before combining them.

Important Advice

Share a complete list of medicines, vitamins, supplements, and herbal products with your healthcare professional before starting Resihance Tablet. Do not start or stop any medicine without specialist guidance.