Eurepa Tablet (Repaglinide)

Essential Safety Advice to Follow When Using Eurepa Tablet (Repaglinide)

• Hypersensitivity: In Diabetes management, Individuals with a known hypersensitivity to Repaglinide Medication should avoid its use.
• Type 1 Diabetes: Repaglinide is not suitable for managing type 1 diabetes, as it requires some residual insulin secretion from the pancreas.
• Pregnancy and Breastfeeding: Pregnant and breastfeeding individuals should consult their healthcare providers before using Repaglinide, as its safety during these conditions is not well established.
• Renal Impairment: Dose adjustments may be necessary in patients with renal impairment to prevent the accumulation of the medication in the body.
• Stressful Conditions: During periods of illness, surgery, or high stress, blood sugar levels may become difficult to control. Consult a doctor regarding appropriate adjustments to the medication regimen.

Some of the specific indications for Eurepa Tablet (Repaglinide) include

• Type 2 Diabetes Management: Repaglinide is primarily used to control blood sugar levels in individuals with type 2 diabetes. It helps stimulate insulin release, particularly after meals, to prevent hyperglycemia.
• Adjunct to Diet and Exercise: This medication is most effective when used as part of a comprehensive treatment plan that includes a balanced diet and regular physical activity.
• Monotherapy or Combination Therapy: Repaglinide can be prescribed as a monotherapy (single-drug therapy) or in combination with other antidiabetic medications to achieve optimal glycemic control.
• Postprandial Glucose Control: Repaglinide is particularly effective in managing postprandial (after-meal) glucose levels, making it useful for individuals who experience significant blood sugar spikes after eating.
• Insulin Resistance: It can also assist in addressing insulin resistance, a common feature of type 2 diabetes. 

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Crucial Side Effects to Be Observed When Using Eurepa Tablet (Repaglinide)

• Hypoglycemia: The most common side effect of Repaglinide is hypoglycemia. Early signs include sweating, shakiness, and irritability. Prompt consumption of glucose-rich foods or beverages can help alleviate mild hypoglycemic episodes.
• Weight Gain: Some individuals may experience weight gain while taking Repaglinide, although the extent of weight gain is generally less compared to other diabetes medications like sulfonylureas.
• Gastrointestinal Distress: Nausea, diarrhea, and abdominal pain are potential gastrointestinal side effects that may occur, but they usually subside as the body adjusts to the medication.
• Allergic Reactions: In rare cases, allergic reactions such as rash, itching, and swelling might occur. Seek medical attention if these symptoms manifest.
• Liver Function: Repaglinide may affect liver function in some individuals. Regular monitoring of liver enzymes is recommended, and the medication should be used cautiously in patients with pre-existing liver conditions.

Frequently Asked Queries About Repaglinide (Eurepa, Prandin) - Managing Type 2 Diabetes

Q1. Can Repaglinide be used alone to treat diabetes?

No, Repaglinide is typically used as part of a comprehensive treatment plan that includes a balanced diet and exercise. It can be used alone or in combination with other antidiabetic medications to effectively manage blood sugar levels in type 2 diabetes.

Q2. How quickly does Repaglinide start working?

Repaglinide has a rapid onset of action, usually within 15-30 minutes after ingestion. It stimulates insulin release from the pancreas, making it particularly useful for controlling post-meal glucose spikes.

Q3. Can Repaglinide cause weight loss?

Unlike some other diabetes medications, Repaglinide is less likely to cause significant weight gain. In fact, some individuals may experience mild weight loss due to improved glucose control and reduced hyperglycemia-associated fluid retention.

Q4. Is Repaglinide safe for elderly individuals?

Yes, Repaglinide can be used in elderly patients, but caution is advised. They may be more sensitive to its effects and could require lower starting doses to avoid hypoglycemia. Regular monitoring and adjustments are crucial to ensure safe and effective use.

Q5. Can Repaglinide be taken by people with liver problems?

Repaglinide should be used cautiously in individuals with pre-existing liver conditions. Regular monitoring of liver enzymes is recommended. Patients with severe liver impairment should generally avoid Repaglinide due to potential alterations in drug metabolism and clearance.

Significant Drug Interactions that Require Attention For Eurepa Tablet (Repaglinide)

• Gemfibrozil: Concurrent use of Repaglinide with gemfibrozil, a lipid-lowering medication, can significantly increase the risk of hypoglycemia and should be avoided.
• Strong CYP2C8 Inhibitors: Medications that inhibit the CYP2C8 enzyme, such as trimethoprim and montelukast, can lead to elevated Repaglinide levels, increasing the risk of hypoglycemia.
• Beta-Blockers: Nonselective beta-blockers can mask the symptoms of hypoglycemia and potentially prolong its duration.
• Alcohol: Alcohol consumption can potentiate the hypoglycemic effects of Repaglinide and increase the risk of low blood sugar levels.
• Thiazolidinediones (TZDs): Concomitant use of Repaglinide with TZDs can enhance its blood sugar-lowering effects, necessitating close monitoring to prevent hypoglycemia.