Janumet Tablet (Sitagliptin + Metformin) | Used to Manage Type 2 Diabetes & Control Blood Sugar

Precaution

• Kidney Function: Tell your doctor if you have kidney disease or reduced kidney function. Janumet contains Metformin, which is eliminated through the kidneys. Kidney function should be assessed before and during treatment as appropriate.
• Lactic Acidosis: Metformin can rarely cause a serious condition called lactic acidosis. The risk is higher with significant kidney impairment and certain other conditions. Seek immediate medical attention if you develop severe weakness, unusual sleepiness, difficulty breathing, persistent vomiting, abdominal discomfort, feeling unusually cold, or a slow or irregular heartbeat.
• Pancreatitis: Sitagliptin has been associated with reports of acute pancreatitis. Contact your doctor promptly if you develop persistent or severe abdominal pain, particularly if the pain may extend toward the back.
• Liver Problems: Tell your doctor if you have liver disease or abnormal liver function. Your healthcare professional will determine whether Janumet is appropriate.
• Excessive Alcohol: Avoid excessive alcohol consumption because alcohol can increase the risk of Metformin-associated lactic acidosis.
• Dehydration: Severe dehydration caused by persistent vomiting, diarrhea, fever, or inadequate fluid intake can affect kidney function and increase risks associated with Metformin.
• Heart Conditions: Inform your doctor if you have serious or unstable heart problems or other conditions associated with reduced oxygen supply to tissues.
• Iodinated Contrast: Tell your healthcare professional if you are scheduled for an X-ray, CT scan, or another procedure involving iodinated contrast material. Janumet may need to be temporarily discontinued in certain situations.

Usage 

• Take Janumet Tablet exactly as prescribed by your doctor.
• The dose depends on your current blood glucose control, kidney function, previous diabetes treatment, and the specific Janumet strength prescribed.
• Janumet is generally taken with meals to reduce the gastrointestinal side effects associated with Metformin.
• Take the tablet at the time recommended by your healthcare professional.
• Swallow the tablet with water. If you are prescribed an extended-release formulation, swallow it whole unless your product's instructions state otherwise.
• Do not crush, split, or chew an extended-release tablet unless specifically instructed by your healthcare professional.
• Continue following your recommended diet and exercise plan.
• Monitor your blood glucose as advised.

Uses

Janumet Tablet is used to:

• Manage Type 2 Diabetes: Helps improve blood glucose control in adults with type 2 diabetes.
• Lower Elevated Blood Sugar: Combines Sitagliptin and Metformin to help reduce elevated blood glucose through different mechanisms.
• Improve Insulin Response: Metformin improves the body's sensitivity to insulin, while Sitagliptin supports glucose-dependent insulin release.
• Reduce Excessive Glucose Production: Metformin primarily reduces glucose production by the liver.
• Support Glycemic Control: Used together with an appropriate diet and regular physical activity.
• Provide Combination Treatment: May be used when treatment with both Sitagliptin and Metformin is appropriate.

Side Effects

Common Side Effects

Possible side effects may include:

• Nausea
• Diarrhea
• Abdominal discomfort
• Headache
• Upper respiratory tract symptoms
• Nasal congestion or sore throat
• Vomiting
• Changes in taste

Gastrointestinal effects are particularly associated with Metformin and may be more noticeable when treatment is first started.

Serious Side Effects

Seek medical attention if you develop:

• Severe or persistent abdominal pain, which may indicate pancreatitis
• Severe weakness or unusual tiredness
• Difficulty breathing
• Persistent vomiting
• Severe dizziness or unusual sleepiness
• Symptoms of lactic acidosis
• Severe allergic reactions
• Swelling of the face, lips, tongue, or throat

FAQs

1. What is Janumet Tablet used for?
Janumet is used with diet and exercise to help improve blood sugar control in adults with type 2 diabetes.

2. What are the ingredients in Janumet?
Janumet contains two active ingredients: Sitagliptin and Metformin.

3. How does Janumet work?
Sitagliptin helps increase glucose-dependent insulin release and reduce glucagon secretion, while Metformin reduces glucose production by the liver and improves insulin sensitivity.

4. When should Janumet be taken?
Janumet is generally taken with meals. Follow the exact schedule and dose prescribed by your doctor.

5. Can Janumet cause low blood sugar?
The risk can increase when Janumet is used with insulin or medicines such as sulfonylureas. The risk is generally lower when Janumet is used without these medicines.

6. Can Janumet be used with other diabetes medicines?
It may be used as part of a combination diabetes treatment plan when prescribed by a healthcare professional.

7. What are the common side effects of Janumet?
Common effects can include nausea, diarrhea, abdominal discomfort, headache, and upper respiratory symptoms.

8. Can Janumet cause stomach problems?
Yes. Metformin may cause nausea, diarrhea, abdominal discomfort, or other gastrointestinal effects, particularly when treatment is first started.

Interactions

• Insulin: Using Janumet with insulin may increase the risk of low blood sugar. Your doctor may monitor your glucose levels and adjust the insulin dose when necessary.
• Sulfonylureas: Medicines such as glimepiride or glipizide can increase insulin release. When combined with Sitagliptin, the risk of hypoglycemia may increase. Your doctor may adjust the dose of the sulfonylurea.
• Other Antidiabetic Medicines: Taking Janumet with additional medicines that lower blood glucose can affect overall glucose levels. Your healthcare professional may recommend additional monitoring.
• Iodinated Contrast Media: Metformin may need to be temporarily discontinued around certain imaging procedures involving iodinated contrast, particularly in patients with specific kidney-function risk factors.
• Alcohol: Excessive alcohol consumption can increase the risk of Metformin-associated lactic acidosis and may also make blood glucose control less predictable.
• Medicines Affecting Kidney Function: Certain medicines can affect kidney function and may alter the safety of Metformin. Tell your doctor about medicines you take regularly, especially if they may affect your kidneys.
• Diuretics: Some water tablets can affect kidney function or blood glucose levels. Inform your doctor if you are taking a diuretic.
• Corticosteroids: Corticosteroids may increase blood glucose levels and can make diabetes more difficult to control. Blood glucose monitoring may be needed when these medicines are started or stopped.
• Strong Enzyme Inducers: Certain medicines may affect Sitagliptin exposure and potentially alter its effectiveness. Your doctor should review your medication list before starting Janumet.