M.V.I. Injection (multi-vitamin injection) | Used for Vitamin Deficiency & Nutritional Support

Precaution

• M.V.I. Injection should be administered only by appropriately trained healthcare professionals.
• Do not administer the product as a direct, undiluted intravenous injection.
• Check the formulation and product instructions before preparation.
• Tell the healthcare professional about any known allergy to vitamins or inactive ingredients.
• M.V.I. Injection is contraindicated in patients with existing hypervitaminosis or hypersensitivity to its components.
• Patients with kidney impairment may require monitoring of renal function, calcium, phosphorus, aluminum, and vitamin A levels.
• Patients with liver disease or high alcohol consumption may require monitoring of vitamin A levels.
• Prolonged parenteral administration may require attention to aluminum exposure, particularly in patients with impaired kidney function.
• Vitamin concentrations may need periodic monitoring to identify deficiencies or excessive vitamin levels.
• Vitamin K may affect the response to warfarin and other anticoagulant therapy.
• Inform the healthcare professional about all prescription medicines, over-the-counter medicines, vitamins, and supplements.
• M.V.I. Injection may interfere with some laboratory tests, including urine glucose testing because of its vitamin C content.
• It may interfere with evaluation of megaloblastic anemia; the product should be avoided before appropriate blood sampling when such a diagnosis is suspected or being evaluated.
• Seek immediate medical attention if signs of a serious allergic reaction occur, such as difficulty breathing, wheezing, swelling, or widespread hives.
• Store the product according to the manufacturer's instructions and protect it from excessive light where required.

Usage

M.V.I. Injection is administered by a healthcare professional as part of a parenteral nutrition regimen.

The product must be prepared and diluted according to the specific manufacturer's instructions and the prescribed nutritional regimen. Current U.S. labeling specifies that the adult formulation is diluted in an appropriate intravenous dextrose, saline, or similar infusion solution before administration.

It should not be injected directly or administered undiluted. The exact amount and frequency are determined according to the patient's nutritional requirements, medical condition, laboratory findings, and other components of parenteral nutrition.

The current U.S. adult labeling lists a recommended daily dose of 10 mL for the labeled formulation, but dosing and preparation should always follow the specific product label and healthcare professional's instructions.

Blood vitamin concentrations may be monitored during treatment to determine whether additional supplementation or adjustment is required.

Uses

1. Prevention of Vitamin Deficiency During Parenteral Nutrition

M.V.I. Injection is used to provide multiple vitamins to patients receiving parenteral nutrition when nutritional requirements are being supplied through intravenous nutrition.

2. Multiple Vitamin Supplementation

It provides a combination of water-soluble and fat-soluble vitamins, including vitamins A, D, E, K, C, B-complex vitamins, folic acid, biotin, and vitamin B12.

3. Vitamin Supplementation When Oral Intake Is Inadequate

M.V.I. Injection may be used when vitamins cannot be adequately provided through oral or enteral nutrition and intravenous nutritional support is required.

4. Nutritional Support During Parenteral Feeding

It can be incorporated into a parenteral nutrition regimen to help meet the body's daily vitamin requirements.

5. Prevention of Multiple Vitamin Deficiencies

The combination of several vitamins helps prevent deficiencies that may develop when patients are unable to obtain sufficient vitamins from their usual diet or enteral nutrition.

6. Vitamin Support During Prolonged Parenteral Nutrition

Patients receiving parenteral nutrition for an extended period may require ongoing vitamin supplementation, with the specific regimen determined by their nutritional and clinical requirements.

7. Support for Normal Metabolic Functions

The vitamins supplied by M.V.I. Injection participate in various normal body processes, including energy metabolism, red blood cell formation, nervous-system function, tissue maintenance, and other physiological activities.

Side Effects

M.V.I. Injection can cause side effects, although not everyone experiences them.

Possible Side Effects

• Skin rash
• Redness (erythema)
• Itching (pruritus)
• Headache
• Dizziness
• Agitation
• Anxiety
• Double vision (diplopia)

Allergic Reactions

Serious hypersensitivity reactions, including anaphylactic or anaphylactoid reactions, have been reported. Symptoms may include:

• Difficulty breathing
• Wheezing
• Swelling of the face, lips, tongue, or throat
• Widespread hives
• Severe dizziness

Immediate medical attention is required if these symptoms occur.

Excess Vitamin Effects

Excessive vitamin exposure can cause toxicity from individual components. Vitamin A toxicity is of particular concern in certain patients, including some people with kidney or liver impairment. Symptoms requiring medical evaluation can include nausea, vomiting, headache, dizziness, or visual changes.

FAQs

1. What is M.V.I. Injection?

M.V.I. Injection is a combination of multiple vitamins formulated for intravenous infusion after dilution. It is used as part of parenteral nutrition to help prevent vitamin deficiencies.

2. What does M.V.I. Injection contain?

The adult formulation contains vitamins A, D, E, K1, C, B1, B2, B6, niacinamide, dexpanthenol, folic acid, biotin, and vitamin B12.

3. What is M.V.I. Injection used for?

It is used to help prevent vitamin deficiencies in adults and children aged 11 years and older who are receiving parenteral nutrition.

4. Is M.V.I. Injection given directly into a vein?

It is administered by intravenous infusion after appropriate dilution. The current labeling states that it should not be administered as a direct, undiluted intravenous injection.

5. Who administers M.V.I. Injection?

It should be prepared and administered by qualified healthcare professionals because it requires appropriate dilution, sterile preparation, and intravenous infusion.

6. Can M.V.I. Injection be used for vitamin deficiency?

It is indicated for prevention of vitamin deficiency in patients receiving parenteral nutrition. Long-standing or specific vitamin deficiencies may require additional targeted treatment based on laboratory assessment.

7. Can M.V.I. Injection cause allergic reactions?

Yes. Hypersensitivity reactions, including serious allergic reactions, have been reported. Difficulty breathing, wheezing, swelling, or widespread hives require immediate medical attention.

8. Can M.V.I. Injection affect warfarin?

Yes. Vitamin K in the formulation can reduce the anticoagulant effect of warfarin. INR or other appropriate coagulation monitoring may be required.

Interactions

M.V.I. Injection contains several vitamins that can affect or be affected by certain medicines.

Warfarin and Other Anticoagulant Therapy

Vitamin K in M.V.I. Injection can reduce the anticoagulant effect of warfarin. Patients receiving warfarin may require periodic monitoring of prothrombin time or INR and adjustment of anticoagulant therapy by their healthcare professional.

Phenytoin

Folic acid may reduce phenytoin blood concentrations and could increase the risk of reduced seizure control.

Methotrexate

Folic acid may reduce the response to methotrexate in certain treatment settings. The treating healthcare professional should assess this combination.

Levodopa

Pyridoxine (vitamin B6) can reduce blood levels and the effects of levodopa when levodopa is given without a dopa-decarboxylase inhibitor.

Certain Antibiotics

The product labeling identifies potential interactions involving vitamins such as thiamine, riboflavin, pyridoxine, niacinamide, and ascorbic acid with certain antibiotics.

Bleomycin

Ascorbic acid and riboflavin may reduce the activity of bleomycin according to the product labeling.

Other Medicines and Supplements

Tell the healthcare professional about all medicines, nutritional products, vitamins, and supplements being used. The complete parenteral nutrition formulation should also be reviewed for compatibility before administration.