Martifur MR Tablet (Nitrofurantoin)

Buy Martifur MR Tablet (Nitrofurantoin), Nitrofurantoin is a widely used antibiotic medication that belongs to the nitrofuran class. It is commonly prescribed to treat urinary tract infections (UTIs) caused by certain bacteria. Available under various brand names, such as Martifur MR, Furadantin, and Macrodanti.

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Martifur MR 50 Tablet (Nitrofurantoin 50mg)

Package QTY Price Add To Cart
30 Tablet/s $13.00
60 Tablet/s $26.00
90 Tablet/s $40.00

Martifur MR 100 Tablet (Nitrofurantoin 100mg)

Package QTY Price Add To Cart
30 Tablet/s $18.00
60 Tablet/s $40.00
90 Tablet/s $54.00

Introduction of Martifur MR Tablet (Nitrofurantoin)

Nitrofurantoin is a widely used antibiotic medication that belongs to the nitrofuran class. It is commonly prescribed to treat urinary tract infections (UTIs) caused by certain bacteria. Available under various brand names, such as Martifur MR, Furadantin, and Macrodantin, nitrofurantoin plays a crucial role in combating bacterial infections and ensuring patient well-being. 

How Nitrofurantoin Works:

Nitrofurantoin operates as a bactericidal Antibiotic, meaning it actively kills bacteria rather than just inhibiting their growth. Upon ingestion, the drug is absorbed in the stomach and intestines, reaching the urinary system through the bloodstream.

Inside the urinary tract, Nitrofurantoin is primarily concentrated in the urine. It exerts its antibacterial effects by disrupting several crucial bacterial processes:

Cell Wall Formation Inhibition: Nitrofurantoin interferes with the synthesis of bacterial cell walls, weakening their structural integrity. This disruption ultimately leads to the destruction of bacterial cells.

DNA Damage: The drug's metabolites interfere with bacterial DNA, causing damage and preventing proper replication and transcription. This hinders bacterial growth and division.

Respiration Interference: Nitrofurantoin impairs bacterial respiration by interfering with enzymes involved in energy production. This further weakens the bacteria's ability to survive and multiply.

Ribosomal Dysfunction: Nitrofurantoin interferes with bacterial ribosomes, the cellular structures responsible for protein synthesis. This disruption hampers the production of essential proteins, hindering bacterial survival.

Nitrofurantoin Tablet Uses:

Nitrofurantoin Tablet is primarily used for treating lower urinary tract infections caused by susceptible bacteria. It can also serve as prophylaxis to prevent recurrent UTIs in certain individuals. Its bacterial spectrum includes both Gram-positive and Gram-negative bacteria, making it a versatile option for managing UTIs.

Martifur MR Tablet (Nitrofurantoin) Dosage Information:

  • Standard Dosage: The typical adult dosage of nitrofurantoin is 50-100 mg taken orally every 6 hours for a span of 7 days. For long-term prophylaxis, the dosage may be reduced to 50-100 mg daily at bedtime.
  • Dosage for Renal Impairment: In patients with impaired renal function, dosage adjustments are necessary to prevent potential adverse effects. For those with a creatinine clearance (CrCl) of 30-60 mL/min, a reduced dose of 50 mg per day is advised. When CrCl is below 30 mL/min, nitrofurantoin is generally contraindicated due to the increased risk of toxicity.
  • Missed Dose: If a dose is missed, it should be taken as soon as remembered. However, if it's closer to the next scheduled dose, the missed one should be skipped to avoid doubling up. It's important not to take extra doses to compensate for missed ones.
  • Overdose: In case of overdose, symptoms may include nausea, vomiting, abdominal pain, and dizziness. Immediate medical attention is essential if an overdose is suspected. Supportive measures and drug discontinuation might be necessary.

Nitrofurantoin Tablet 100mg:

Nitrofurantoin Tablet 100mg is an oral antibiotic medication used to treat urinary tract infections (UTIs). It belongs to the nitrofuran class and works by inhibiting bacterial growth. This dosage is commonly prescribed and helps combat Bacterial Infections effectively.

Alternatives to Nitrofurantoin Tablet:

If Nitrofurantoin Tablet is not suitable or effective for a patient, alternatives such as ciprofloxacin, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanate might be considered. However, the choice of an alternative depends on factors like bacterial susceptibility and patient-specific conditions.

Nitrofurantoin Tablet for UTI:

Nitrofurantoin Tablet is a well-established treatment for uncomplicated urinary tract infections (UTIs). It targets the bacteria responsible for the infection, providing relief from symptoms like pain and discomfort during urination. It is particularly effective against Escherichia coli, a common UTI-causing bacterium.

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When Using Martifur MR Tablet (Nitrofurantoin), It Is Important To Take Certain Precautions

  • Allergic Reactions: Individuals with a history of hypersensitivity to nitrofurantoin/Macrodantin or other nitrofuran derivatives should avoid its use.
  • Renal Impairment: Nitrofurantoin's dose adjustment is crucial in patients with renal impairment to prevent potential toxic effects.
  • Pregnancy: Nitrofurantoin should be used cautiously during pregnancy, particularly in the last month, due to the risk of hemolytic anemia in newborns.
  • Elderly Patients: Elderly individuals may be more susceptible to side effects, such as pulmonary reactions and neuropathy, and should be closely monitored.
  • Diabetes: Diabetic patients should be aware that nitrofurantoin may interfere with urine glucose tests, leading to false results.

Some of the specific indications for Macrodantin Tablets include

  1. UTI Treatment: Nitrofurantoin is primarily prescribed for treating uncomplicated lower urinary tract infections caused by susceptible bacteria.
  2. UTI Prophylaxis: It can also be used as prophylaxis to prevent recurrent UTIs, especially in individuals prone to such infections.
  3. Bacterial Spectrum: Nitrofurantoin is effective against a range of Gram-positive and Gram-negative bacteria, including Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus.
  4. Alternative to Sulfa Drugs: Nitrofurantoin is often used as an alternative to sulfa drugs in patients allergic to sulfonamides.
  5. Pediatric UTIs: In pediatric patients, nitrofurantoin is sometimes prescribed for urinary tract infections, but caution and proper dosage adjustments are essential.

Crucial Side Effects to Be Observed When Using Martifur MR Tablet (Nitrofurantoin)

  • Gastrointestinal Distress: Common side effects include nausea, vomiting, and loss of appetite. Taking the medication with food can help alleviate these symptoms.
  • Pulmonary Reactions: Nitrofurantoin may rarely cause severe pulmonary reactions, including acute and subacute pneumonitis. Patients experiencing symptoms like cough, fever, and difficulty breathing should seek medical attention.
  • Hematologic Effects: Hemolytic anemia, leukopenia, and thrombocytopenia have been reported, although these are relatively rare.
  • Neuropathy: Prolonged use of nitrofurantoin can lead to peripheral neuropathy, resulting in numbness, tingling, or weakness in the extremities.
  • Hepatotoxicity: Hepatic dysfunction, hepatitis, and jaundice are potential side effects, necessitating close monitoring of liver function during treatment.

Frequently Asked Queries About Martifur MR Tablet (Nitrofurantoin)

Q1. Can Nitrofurantoin treat respiratory infections?

No, Nitrofurantoin is not suitable for treating respiratory infections like pneumonia or bronchitis. It is primarily used for urinary tract infections caused by specific bacteria.

Q2. Can I take Nitrofurantoin while breastfeeding?

Nitrofurantoin can pass into breast milk, potentially affecting the nursing infant. Consult your healthcare provider before taking it while breastfeeding to assess the benefits and potential risks.

Q3. Are there any interactions with birth control pills?

Nitrofurantoin does not interfere with the effectiveness of birth control pills. However, using additional contraceptive methods, like condoms, is recommended during antibiotic use to prevent potential interactions.

Q4. Is Nitrofurantoin effective against sexually transmitted infections (STIs)?

No, Nitrofurantoin is not intended to treat or prevent sexually transmitted infections. It is specifically designed for bacterial urinary tract infections and should not be relied upon for STI protection.

Q5. Can Nitrofurantoin be used for kidney infections (pyelonephritis)?

In most cases, Nitrofurantoin is not the first-line treatment for kidney infections. It is more commonly prescribed for lower urinary tract infections. Kidney infections often require different antibiotics and closer medical supervision.

Combining different drugs with Martifur MR Tablet (Nitrofurantoin) can lead to Adverse Effects

  1. Antacids: Concurrent use of nitrofurantoin with magnesium trisilicate-containing antacids can reduce its absorption, potentially decreasing its effectiveness.
  2. Probenecid: Probenecid can inhibit the renal excretion of nitrofurantoin, leading to increased blood levels and potential toxicity.
  3. Warfarin: Nitrofurantoin may enhance the anticoagulant effects of warfarin, necessitating careful monitoring of prothrombin time.
  4. Methotrexate: Nitrofurantoin can interfere with methotrexate's renal tubular transport, potentially leading to increased methotrexate levels.
  5. Sulfinpyrazone: Co-administration with sulfinpyrazone can lead to elevated nitrofurantoin blood levels and an increased risk of toxicity.
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Manufacturer : Walter Bushnell, India
Equivalent Brand : Macrodantin
Generic Search : Nitrofurantoin