Benoquin Ointment (Monobenzone)
Benoquin Cream 20% and 40% (Monobenzone) is a prescription depigmenting topical medicine used to remove remaining skin pigmentation in people with generalized vitiligo. Monobenzone Cream works by reducing melanin production which helps create an even skin tone across depigmented and normally pigmented areas. Common side effects include redness, dryness and inflammation.
Benoquin Cream 20% & 40% contains Monobenzone, a depigmenting a topical medication specifically prescribed for patients with extensive vitiligo. Unlike skin-lightening creams such as hydroquinone, monobenzone cream permanently removes pigmentation from normally colored skin to match vitiligo-affected areas.
It works by breaking down melanin in skin cells, leading to gradual depigmentation over several months. Treatment is typically recommended only when more than 50% of the body surface is affected by vitiligo and the goal is to achieve uniform depigmentation.
This medicine should be used under the supervision of a qualified dermatologist.
A comparison between Monobenzone and Hydroquinone:
| Feature | Monobenzone (MBEH) 20% & 40% | Hydroquinone (HQ) |
| Primary Use | Final depigmentation for extensive vitiligo (usually >50% body coverage). | Treatment of hyperpigmentation (melasma, age spots, acne scars). |
| Mechanism | Melanocytotoxic: Directly destroys melanocytes (the cells that make pigment). | Tyrosinase Inhibitor: Slows down pigment production without killing the cells. |
| Permanence | Permanent & Irreversible. It wipes out the skin's ability to tan or produce color. | Reversible. Pigmentation usually returns once the treatment is stopped. |
| Effect Radius | Systemic: Can cause "distant depigmentation" (lightening in areas where it wasn't applied). | Local: Lightens only the specific area where the cream is applied. |
| FDA Status | Approved specifically for vitiligo (e.g., brand name Benoquin). | Approved as the gold standard for skin lightening. |
| Typical Strength | 20% & 40% (standard prescription strength). | 2% (OTC) to 4% (prescription); up to 10% in some compounded formulas. |
| Common Brand | Benoquin | Eukroma Cream, Melalite Forte Cream. |
Note: Monobenzone is not a cosmetic skin-lightening product and should not be used for tanning reduction or complexion lightening in healthy individuals.
Precautions:
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Use only under medical guidance
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Avoid application on broken or inflamed skin
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Limit sun exposure and use high-SPF sunscreen daily
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Wear protective clothing outdoors
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Avoid contact with eyes, lips, and mucous membranes
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May cause permanent skin depigmentation
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Stop use if severe irritation or blistering occurs
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Not recommended in pregnancy or breastfeeding unless advised by a doctor
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Keep out of reach of children aged 12 and below
Uses of Benoquin Ointment:
Monobenzone is specifically prescribed for:
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Depigmentation therapy in generalized vitiligo
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Helps create a uniform skin tone
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Reduces psychological distress associated with patchy pigmentation
Side Effects of Benoquin Ointment:
While effective, Monobenzone Cream may cause side effects, including:
Common Side Effects:
- Mild burning or irritation at the application site
- Redness or swelling of the treated skin
- Dryness or flaking of the skin
Severe Side Effects:
- Severe skin irritation
- Intense itching
- Severe burning sensation
- Redness or swelling of the treated skin
If severe side effects occur, discontinue use and consult a healthcare professional immediately.
FAQs:
Q. What is Monobenzone Cream used for?
A. Monobenzone (Benoquin Cream) is used to depigment normal skin in people with generalized vitiligo, helping achieve an even skin tone.
Q. Can Monobenzone Cream be used for cosmetic skin lightening?
A. No, Monobenzone is not recommended for cosmetic skin lightening. It is intended for depigmenting normal skin in patients with extensive vitiligo to achieve an even skin tone.
Q. How long does it take to see results with Monobenzone Cream?
A. Depigmentation is usually accomplished after one to four months of treatment. If satisfactory results are not obtained after four months, consult your physician.
Drugs.com
Q. Can Monobenzone causes permanent depigmentation?
A. Yes, Monobenzone causes permanent depigmentation of the skin.
Q. Can I use Monobenzone Cream if I am pregnant or breastfeeding?
A. It is not known whether Monobenzone will harm an unborn baby or if it passes into breast milk. Consult your doctor before using this medication if you are pregnant or breastfeeding.
Interactions:
There are no major systemic drug interactions, as monobenzone cream acts locally on the skin. However:
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Avoid combining with other strong depigmenting or exfoliating agents unless approved by your doctor
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Inform your dermatologist about:
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topical steroids
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retinoids
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benzoyl peroxide
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herbal creams or peels
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| Manufacturer | : | Brinton Pharmaceuticals Pvt Ltd |
| Equivalent Brand | : | Monobenzone |
| Generic Search | : | Monobenzone |
