Onglyza Tablet (Saxagliptin)

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Buy Onglyza Tablet (Saxagliptin), Saxagliptin, commonly marketed under the brand name Onglyza, is a medication primarily prescribed for the management of diabetes mellitus

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Onglyza 2.5mg Tablet (Saxagliptin 2.5mg)

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28 Tablet/s $40.02
56 Tablet/s $80.10
84 Tablet/s $120.15

Onglyza 5mg Tablet (Saxagliptin 5mg)

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28 Tablet/s $44.40
56 Tablet/s $89.00
84 Tablet/s $133.50

Introduction to Saxagliptin Tablet (Onglyza)

Saxagliptin, commonly marketed under the brand name Onglyza, is a medication primarily prescribed for the management of diabetes mellitus. Diabetes is a chronic metabolic disorder characterized by elevated blood sugar levels due to either insufficient insulin production or the body's inability to utilize insulin effectively. Saxagliptin belongs to a class of medications known as dipeptidyl peptidase-4 (DPP-4) inhibitors, which play a crucial role in regulating blood sugar levels by enhancing insulin secretion and reducing glucagon release from the pancreas. Saxagliptin received FDA approval for the treatment of Type 2 Diabetes mellitus. This approval followed a rigorous evaluation of its safety and efficacy in clinical trials, making it a trusted option in diabetes management in the United States.

Dosage Information for Saxagliptin (Onglyza)

Recommended Dosage

  • The typical starting dose of Saxagliptin is 2.5 mg once daily, administered orally, with or without food.
  • Depending on individual response and glycemic control, the dose can be increased to 5 mg once daily.
  • For patients with moderate to severe renal impairment, a lower starting dose of 2.5 mg daily is advisable.
  • It is crucial to follow the healthcare provider's prescribed dosage, as they will determine the most appropriate Saxagliptin regimen based on your specific medical condition and other factors.

Missed Dose

  • If you forget to take a dose of Saxagliptin Tablet, take it as soon as you remember, unless it is close to the time for your next scheduled dose.
  • In case your next dose is approaching, skip the missed dose and resume your regular dosing schedule.
  • Never double the dose to compensate for a missed one, as this can increase the risk of side effects or complications.


  • An overdose of Saxagliptin may lead to hypoglycemia (low blood sugar), which can cause symptoms like shakiness, sweating, confusion, and fainting.
  • If you suspect an overdose or experience severe hypoglycemic symptoms, seek immediate medical attention or contact a poison control center. To prevent overdose, strictly adhere to the prescribed dosage and do not self-adjust your Saxagliptin intake. 

Saxagliptin Benefits:

Saxagliptin offers several benefits for individuals with type 2 diabetes. It helps improve glycemic control, provides long-term blood sugar regulation, is generally weight-neutral, and may have potential cardiovascular advantages.

Saxagliptin vs. Other Diabetes Medications:

When comparing Saxagliptin to other diabetes medications, it's important to consider individual factors such as efficacy, side effects, and patient preferences. Saxagliptin is one of many options available, and the choice of medication should be made in consultation with a healthcare provider.

Saxagliptin Prescription:

Saxagliptin is available by prescription only. Healthcare providers prescribe it based on a patient's specific medical condition, diabetes management goals, and any contraindications or potential drug interactions. If Prescribed, explore

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To ensure the safe and effective use of Onglyza Tablet (Saxagliptin), it is essential to observe certain precautions:

  • Allergies and Hypersensitivity: Inform your healthcare provider if you have a history of allergies, especially if you have experienced allergic reactions to medications, including Saxagliptin.
  • Pancreatic Conditions: Individuals with a history of pancreatitis should exercise caution when using Saxagliptin, as it may increase the risk of pancreatitis.
  • Hypoglycemia Risk: Saxagliptin can lead to hypoglycemia, particularly when combined with other diabetes medications that lower blood sugar. Be vigilant about monitoring your blood sugar levels and follow your healthcare provider's guidance on medication usage.
  • Renal Impairment: Patients with moderate to severe renal impairment may require dose adjustments or alternative treatments, as Saxagliptin is primarily eliminated through the kidneys.
  • Pregnancy and Breastfeeding: Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Saxagliptin during these periods is not well-established.

Some of the specific indications for Saxagliptin Tablet (Onglyza) include

Saxagliptin (Onglyza) is primarily employed for the management of diabetes mellitus, specifically in individuals with type 2 diabetes.

  • Type 2 Diabetes Treatment: Saxagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 Diabetes mellitus.
  • Blood Sugar Regulation: It works by enhancing the body's ability to produce insulin and reduce the production of glucose by the liver, ultimately leading to better blood sugar control.
  • Long-term Glycemic Control: Saxagliptin is known for its ability to provide sustained glycemic control over time when used in combination with other Diabetes medications or as a monotherapy.
  • Cardiovascular Benefits: Some studies suggest that Saxagliptin may have cardiovascular benefits, reducing the risk of heart-related complications in individuals with diabetes.
  • Potential Weight Neutrality: Unlike some other diabetes medications, Saxagliptin is generally considered weight-neutral, meaning it is less likely to cause significant weight gain, which is a common concern for individuals with diabetes.

Here are five common side effects associated with Onglyza Tablet (Saxagliptin)

While Saxagliptin is generally well-tolerated, like all medications, it may cause side effects in some individuals.

  • Hypoglycemia: Saxagliptin can lower blood sugar levels, leading to hypoglycemia. Symptoms may include shakiness, sweating, rapid heartbeat, and confusion. It is essential to monitor your blood sugar regularly and be aware of the signs of hypoglycemia.
  • Upper Respiratory Tract Infections: Some individuals may experience upper respiratory tract infections such as the common cold, sore throat, or nasal congestion while taking Saxagliptin.
  • Headache: Headaches are a relatively common side effect and are usually mild to moderate in severity. If persistent or severe, consult your healthcare provider.
  • Pancreatitis: In rare cases, Saxagliptin has been associated with pancreatitis, which can cause severe abdominal pain. If you experience persistent abdominal pain, seek medical attention promptly.
  • Allergic Reactions: Although uncommon, some individuals may develop allergic reactions to Saxagliptin, presenting with symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical assistance if you experience any of these symptoms.

Frequently Asked Queries About Onglyza Tablet (Saxagliptin)

FAQ: Can Saxagliptin (Onglyza) cause significant weight gain?

Answer: Saxagliptin is generally considered weight-neutral, meaning it is less likely to lead to significant weight gain, a common concern in diabetes management.

FAQ: Is Saxagliptin safe for older adults with diabetes?

Answer: Saxagliptin is generally safe for older adults, but dosage adjustments may be necessary for those with renal impairment. Consult your healthcare provider for personalized guidance.

FAQ: Can I drink alcohol while taking Saxagliptin?

Answer: Moderate alcohol consumption is generally acceptable, but excessive alcohol can increase the risk of hypoglycemia. Monitor your blood sugar levels and drink responsibly.

FAQ: Are there any dietary restrictions while on Saxagliptin?

Answer: No specific dietary restrictions are associated with Saxagliptin, but maintaining a balanced diet and monitoring carbohydrate intake can aid in diabetes management.

FAQ: Can Saxagliptin be used in children with type 2 diabetes?

Answer: Saxagliptin is primarily approved for use in adults with type 2 diabetes. Its safety and efficacy in children have not been well-established. Consult a pediatric endocrinologist for appropriate pediatric diabetes management options.

Here are five notable drug interactions with Saxagliptin Tablet (Onglyza)

  • Insulin and Insulin Secretagogues: Combining Saxagliptin with insulin or insulin secretagogues (e.g., sulfonylureas) may increase the risk of hypoglycemia. Dose adjustments may be necessary when using these medications together.
  • Certain Antibiotics: Some antibiotics, such as clarithromycin and erythromycin, can inhibit the metabolism of Saxagliptin, leading to higher blood levels. Your healthcare provider may need to adjust your Saxagliptin dosage if antibiotics are prescribed.
  • CYP3A4 Inducers and Inhibitors: Drugs that induce or inhibit the cytochrome P450 3A4 enzyme system can affect the metabolism of Saxagliptin. Always inform your healthcare provider about any new medications you are taking, including over-the-counter drugs and supplements.
  • ACE Inhibitors: The concomitant use of Saxagliptin with ACE (angiotensin-converting enzyme) inhibitors may increase the risk of angioedema, a severe allergic reaction. Close monitoring is advised if these medications are prescribed together.
  • Thiazolidinediones (TZDs): Saxagliptin can be used in combination with TZDs, but this combination may increase the risk of heart failure. Your healthcare provider will carefully assess the benefits and risks when considering this combination.
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Manufacturer:AstraZeneca, India
Equivalent Brand:Onglyza
Generic Search:Saxagliptin