Syncapone Tablet (Levodopa + Carbidopa + Entacapone)

Syncapone Tablet (Carbidopa + Levodopa + Entacapone) is a prescription medication utilized for the treatment of Parkinson's disease. Its primary purpose is to alleviate excessive shaking by slowing down bodily movements. It is also known as Stalevo.

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Syncapone 50mg Tablet (Levodopa (50mg) + Carbidopa (12.5mg) + Entacapone (200mg))

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Syncapone 100mg Tablet( Levodopa (100mg) + Carbidopa (25mg) + Entacapone (200mg))

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Syncapone 150mg Tablet (Levodopa (150mg) + Carbidopa (37.5mg) + Entacapone (200mg)

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Syncapone Tablet (Carbidopa + Levodopa + Entacapone): Effective for Parkinson's disease

Syncapone Tablet is a medication that combines three active ingredients: Carbidopa, Levodopa, and Entacapone. It is primarily used in the treatment of Parkinson's disease, a progressive neurological disorder. Carbidopa helps enhance the effectiveness of Levodopa in the brain, while Entacapone prolongs the duration of action of Levodopa. It is also sold under the brand name Stalevo.

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Dosage: The dosage of Syncapone Tablet (Carbidopa + Levodopa + Entacapone) may vary depending on the individual's condition and their healthcare provider's instructions. It is important to follow the prescribed dosage and any specific instructions provided by the doctor or pharmacist.

The combination of Carbidopa, Levodopa, and Entacapone provides several benefits:

Relief of Parkinson's symptoms: Levodopa is converted into dopamine in the brain, a neurotransmitter that helps regulate movement and coordination. By supplementing the brain's dopamine levels, Syncapone helps alleviate symptoms such as tremors, stiffness, and slowness of movement.

Improved effectiveness: Carbidopa enhances the effectiveness of Levodopa by preventing its breakdown in the bloodstream before it reaches the brain. This allows for a higher amount of Levodopa to reach the brain, resulting in better symptom control.

Prolonged duration of action: Entacapone inhibits an enzyme that breaks down Levodopa in the body, extending its duration of action. This helps maintain a more consistent and stable level of Levodopa in the brain, reducing fluctuations in symptoms.

How it works: Carbidopa works by inhibiting an enzyme called DOPA decarboxylase outside the brain. This prevents the breakdown of Levodopa into dopamine in peripheral tissues, allowing more Levodopa to reach the brain. Levodopa, a precursor to dopamine, is then converted into dopamine within the brain, replenishing the depleted levels of this neurotransmitter. Entacapone inhibits an enzyme called catechol-O-methyltransferase (COMT), which breaks down Levodopa. By inhibiting COMT, Entacapone prolongs the duration of action of Levodopa, enhancing its therapeutic effect. Together, these three components in Syncapone work synergistically to improve the symptoms of Parkinson's disease.

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Here are some important precautions to keep in mind when using Syncapone Tablet (Carbidopa + Levodopa + Entacapone):

  • Before starting Syncapone, it is essential to consult with your doctor or healthcare provider. They will assess your medical history, current medications, and overall health to determine if Syncapone is suitable for you.

  • The dosage of Syncapone may vary for each person. Your healthcare provider will prescribe the appropriate dosage based on your condition and response to the medication. Follow their instructions carefully and do not adjust the dosage without consulting them.

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  • Syncapone is typically taken multiple times throughout the day. It is important to follow the prescribed schedule and timing of doses. Taking the medication at consistent intervals helps maintain a stable level of medication in the body.

  • Do not stop taking Stalevo abruptly without consulting your doctor. Sudden discontinuation may lead to withdrawal symptoms or a worsening of Parkinson's disease symptoms. Your doctor will guide you on the appropriate way to taper off the medication if needed.

  • If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Syncapone with your doctor. They will provide guidance on whether it is safe to use during these periods.

  • Syncapone may cause drowsiness, dizziness, or blurred vision. Exercise caution while driving or operating machinery until you know how the medication affects you.

 

Utilizations of Stalevo

Syncapone Tablet (Carbidopa + Levodopa + Entacapone) is primarily used in the treatment of Parkinson's disease. It helps alleviate symptoms such as tremors, stiffness, and slowness of movement. 

Some possible side effects of Syncapone Tablet (Carbidopa + Levodopa + Entacapone) include:

Nausea and vomiting: These gastrointestinal symptoms are commonly reported side effects of Syncapone.

Dizziness or lightheadedness: Stalevo may cause dizziness or a feeling of lightheadedness, which can affect balance and coordination.

Drowsiness: Some individuals may experience increased drowsiness or sleepiness while taking Syncapone.

Low blood pressure: Syncapone can cause a decrease in blood pressure, leading to symptoms such as dizziness or fainting.

Dyskinesias: In some cases, Syncapone may cause involuntary movements, known as dyskinesias, which can be similar to the symptoms of Parkinson's disease.

Hallucinations: Syncapone has been associated with hallucinations, particularly in older adults.

Confusion or cognitive changes: Some individuals may experience confusion or changes in cognitive function while taking Syncapone.

Gastrointestinal disturbances: Syncapone may cause abdominal pain, diarrhea, or constipation.

Can Syncapone Tablet cause changes in mood or behavior?

Answer: Yes, Syncapone can, in rare cases, cause changes in mood or behavior. Some individuals may experience increased impulsivity, aggression, or unusual behaviors. If you or your loved ones notice any significant changes, it is important to seek medical advice promptly.

Are there any dietary restrictions while taking Syncapone Tablet?

Answer: Syncapone can be affected by protein-rich diets as they may interfere with the absorption of Levodopa. It is generally recommended to take Syncapone on an empty stomach or with a low-protein meal. However, it is essential to consult your healthcare provider for specific dietary instructions tailored to your needs.

Can Stalevo Tablet interact with herbal supplements or alternative therapies?

Answer: Stalevo may interact with certain herbal supplements, such as St. John's Wort, and alternative therapies. It is crucial to inform your healthcare provider about any herbal supplements or alternative therapies you are using to avoid potential interactions or reduced efficacy of the medication.

Can Syncapone Tablet be used in elderly patients?

Answer: Syncapone can be used in elderly patients, but caution should be exercised due to the increased risk of side effects such as hallucinations, confusion, and low blood pressure. Close monitoring by the healthcare provider is important to ensure safety and optimize treatment outcomes.

Is it safe to drive or operate machinery while taking Syncapone Tablet?

Answer: Syncapone may cause drowsiness, dizziness, or blurred vision, which can impair your ability to drive or operate machinery safely. It is important to assess your individual response to the medication and discuss with your healthcare provider whether it is safe for you to engage in such activities.

 

 

Syncapone Tablets (Carbidopa + Levodopa + Entacapone) may interact with various medications.

MAO inhibitors: Syncapone should not be taken with monoamine oxidase (MAO) inhibitors, as it can lead to a potentially dangerous increase in blood pressure. Examples of MAO inhibitors used in neurology include selegiline and rasagiline.

Antipsychotics: Certain antipsychotic medications used in neurology, such as risperidone or quetiapine, may interact with Syncapone and increase the risk of side effects such as drowsiness, low blood pressure, or worsening of Parkinson's symptoms. Close monitoring by the healthcare provider is necessary.

Antidepressants: Some antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants (TCAs), may interact with Syncapone and increase the risk of serotonin syndrome. Serotonin syndrome is a potentially life-threatening condition characterized by agitation, confusion, rapid heart rate, and increased body temperature.

Blood pressure medications: Stalevo may interact with certain blood pressure medications, such as alpha-blockers or beta-blockers, potentially leading to a drop in blood pressure. It is important to monitor blood pressure closely when combining Syncapone with these medications.

Other Parkinson's medications: Syncapone may interact with other medications used to treat Parkinson's disease, such as dopamine agonists (e.g., pramipexole or ropinirole), leading to an increased risk of side effects. The healthcare provider will carefully consider the combination of medications and adjust the dosages accordingly.

Herbal supplements: Some herbal supplements, such as St. John's Wort, may interact with Syncapone and reduce its effectiveness. Inform your doctor about any herbal supplements you are taking.

More Information Demo
Manufacturer : Sun Pharma, India
Equivalent Brand : Stalevo
Generic Search : Levodopa + Carbidopa + Entacapone