Daparyl Tablet (Dapagliflozin) | For Type 2 Diabetes Mellitus Management, Heart Failure Support, and Chronic Kidney Disease Management
Daparyl Tablet contains dapagliflozin as its active ingredient, an SGLT2 inhibitor that helps manage blood sugar levels in adults with type 2 diabetes. It works by helping the kidneys remove excess glucose from the body through urine.
Product Overview
What Is Daparyl Tablet?
Daparyl Tablet contains dapagliflozin as its active ingredient. It belongs to the sodium-glucose cotransporter 2 (SGLT2) inhibitor group of medicines and is used to help manage blood sugar levels in adults with type 2 diabetes. Daparyl is available in 5 mg and 10 mg strengths.
How Does Daparyl Tablet Work?
Dapagliflozin acts on the SGLT2 protein found in the kidneys. Under normal conditions, this protein helps the body reabsorb glucose from filtered blood back into the bloodstream. Dapagliflozin reduces this reabsorption, allowing more glucose to pass out of the body through urine.
This process helps lower blood glucose levels without relying primarily on increased insulin release. The medicine also affects the body's handling of sodium and water, which contributes to its role in heart failure and chronic kidney disease care.
Role in Type 2 Diabetes Management
In type 2 diabetes, the body may not produce enough insulin or may not respond effectively to it, causing glucose levels to rise. Dapagliflozin helps manage this by increasing the amount of glucose removed through urine.
Daparyl may be used as part of a broader diabetes management plan that includes balanced meals, regular physical activity, and blood glucose monitoring. Depending on individual requirements, dapagliflozin may be used alone or alongside other diabetes medicines.
Role in Heart Health
Dapagliflozin is also used in adults with certain forms of chronic heart failure. By influencing the body's handling of sodium and water, it can help reduce the burden on the heart and lower the risk of worsening heart failure in appropriate patients.
Its role in heart failure management is separate from its blood glucose-lowering effect, so its use is not limited to people with diabetes. The specific indication depends on the individual's clinical assessment.
Role in Kidney Health
Dapagliflozin is used in eligible adults with chronic kidney disease to help slow the progression of kidney function loss and reduce certain related complications. Its effects on kidney function extend beyond glucose removal alone.
The suitability of dapagliflozin depends on factors such as kidney function, the condition being treated, and the individual's overall treatment plan.
Frequently Relevant Product Information
| Detail | Information |
| Brand name | Daparyl |
| Active ingredient | Dapagliflozin, for the single-ingredient formulation |
| Dosage form | Oral tablet |
| Other established roles of dapagliflozin | Chronic heart failure and chronic kidney disease in eligible adults |
| Main treatment area | Type 2 diabetes management |
| Manufacturer | Verify on the specific product packaging |
Precaution
Daparyl Tablet may contain dapagliflozin, an SGLT2 inhibitor used to help manage type 2 diabetes. Confirm the active ingredients and strength on the product packaging before use. The following precautions help support its appropriate use.
1. Kidney Function
Kidney function may need to be assessed before and during treatment, as it can affect the suitability of dapagliflozin.
2. Hydration
Dapagliflozin increases glucose removal through urine and may also increase fluid loss. Maintain adequate fluid intake as advised by your healthcare professional.
3. Blood Sugar Monitoring
Monitor blood glucose regularly, particularly if Daparyl is taken with other diabetes medicines.
4. Low Blood Pressure
Fluid loss may contribute to dizziness or low blood pressure, especially in older adults and people taking medicines that increase urine production.
5. Existing Health Conditions
Inform your healthcare professional about kidney or liver problems, a history of dehydration, or other relevant health conditions before starting treatment.
6. Pregnancy and Breastfeeding
Seek medical advice before using dapagliflozin during pregnancy or breastfeeding, as it may not be suitable in these situations.
7. Surgery or Prolonged Fasting
Inform your healthcare professional before planned surgery or prolonged fasting. Dapagliflozin may need to be temporarily stopped because of the risk of diabetic ketoacidosis.
Usage
Daparyl Tablet contains dapagliflozin in its single-ingredient formulation. It helps manage blood sugar levels in adults with type 2 diabetes. Confirm the tablet's strength and composition on the product packaging before use.
How to Take Daparyl Tablet
Follow instructions: Take the tablet according to your healthcare professional's directions.
With or without food: Dapagliflozin can generally be taken with or without food.
Take consistently: Follow the recommended daily schedule.
Swallow properly: Swallow the tablet with water as directed.
Missed dose: Follow the patient leaflet's instructions and avoid taking an extra dose to compensate.
Uses
Daparyl Tablet contains dapagliflozin in its single-ingredient formulation. It belongs to the SGLT2 inhibitor group and helps manage blood glucose levels. Confirm the active ingredients on the product packaging before use.
1. Management of Type 2 Diabetes
Daparyl helps lower blood sugar levels by allowing the kidneys to remove excess glucose through urine.
2. Chronic Heart Failure
Dapagliflozin is used in eligible adults with chronic heart failure to reduce the risk of worsening heart failure and related complications.
3. Chronic Kidney Disease
Dapagliflozin may help slow the progression of chronic kidney disease and reduce certain related complications in eligible adults.
4. Support for Long-Term Health Management
When appropriate, dapagliflozin can form part of a broader treatment plan alongside regular monitoring and recommended lifestyle changes.
Important: The approved uses depend on the specific product, its formulation, and individual health requirements. Daparyl combination variants may contain additional ingredients with different uses.
Side Effects
Daparyl Tablet may contain dapagliflozin, an SGLT2 inhibitor used to help manage blood sugar levels in adults with type 2 diabetes. Confirm the active ingredients on the product packaging, as side effects may vary with combination formulations.
Common Effects of Daparyl Tablet
1. Increased Urination
Dapagliflozin helps remove excess glucose through urine, which may lead to more frequent urination.
2. Dehydration
Increased fluid loss may cause thirst, dry mouth, or reduced urine output in some situations.
3. Dizziness
Some people may experience dizziness, particularly when fluid levels or blood pressure decrease.
4. Genital Fungal Infections
Higher glucose levels in urine can increase the risk of fungal infections around the genital area.
5. Urinary Tract Infections
Some people may experience symptoms such as burning during urination, frequent urination, or discomfort.
6. Low Blood Sugar
Low blood sugar may occur, especially when dapagliflozin is taken with insulin or certain other diabetes medicines.
FAQs
1. What is Daparyl Tablet used for?
Daparyl Tablet contains dapagliflozin, a medicine used to manage type 2 diabetes. Depending on the patient's condition, it may also be prescribed for heart failure and chronic kidney disease.
2. What is the active ingredient in Daparyl Tablet?
Daparyl Tablet contains dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor that helps the body remove excess glucose through urine.
3. How does Daparyl Tablet work?
Dapagliflozin reduces the reabsorption of glucose in the kidneys, allowing more glucose to leave the body through urine and helping lower blood sugar levels.
4. Can Daparyl Tablet help manage type 2 diabetes?
Yes, it helps control blood sugar levels in adults with type 2 diabetes when used as prescribed, alongside a suitable diet and exercise plan.
5. Can Daparyl Tablet be used for heart failure?
Dapagliflozin may be prescribed to reduce the risk of certain complications and hospitalisation associated with heart failure, as advised by a healthcare professional.
6. What are the common side effects of Daparyl Tablet?
Common side effects may include genital fungal infections, increased urination, and urinary tract infections. Contact your doctor if symptoms persist or worsen.
7. Can Daparyl Tablet cause low blood sugar?
Dapagliflozin alone generally has a low risk of hypoglycaemia, but the risk may increase when it is taken with insulin or certain other diabetes medicines.
8. Can Daparyl Tablet be taken with other diabetes medicines?
It may be prescribed alongside other diabetes medicines. Inform your doctor about all medicines you take so that treatment and blood sugar levels can be monitored appropriately.
9. Who should consult a doctor before taking Daparyl Tablet?
People with kidney problems, dehydration, low blood pressure, or a history of diabetic ketoacidosis should consult their doctor before use. It is not suitable for everyone.
10. How should Daparyl Tablet be stored?
Store Daparyl Tablet according to the product label, in a dry place away from excessive heat and moisture. Keep it out of the reach of children.
Interactions
1. Insulin and Other Diabetes Medicines
Interaction: Taking Daparyl with insulin or medicines such as sulfonylureas may increase the risk of low blood sugar (hypoglycaemia).
Advice: Monitor your blood sugar as recommended by your doctor. Report symptoms such as sweating, shakiness, dizziness, or unusual hunger. Your doctor may need to adjust other diabetes medicines.
2. Diuretics (Water Tablets)
Interaction: Medicines such as furosemide and hydrochlorothiazide increase urine production. When combined with dapagliflozin, they may increase the risk of dehydration, low blood pressure, and dizziness.
Advice: Follow your healthcare professional's guidance on fluid intake and monitoring. Inform your doctor if you experience persistent dizziness, weakness, or reduced urination.
3. Blood Pressure Medicines
Interaction: Medicines used to lower blood pressure may increase the likelihood of low blood pressure when taken with Daparyl, particularly in people who are dehydrated or have reduced kidney function.
Advice: Check your blood pressure as advised and tell your doctor if you experience light-headedness, especially when standing up.
4. Lithium
Interaction: Dapagliflozin may affect how the kidneys handle lithium and can reduce lithium levels in the blood, potentially affecting its therapeutic effect.
Advice: If you take lithium, inform your doctor before starting Daparyl. Your healthcare professional may recommend monitoring lithium levels and adjusting treatment if necessary.
5. Other Diabetes Medicines and Supplements
Interaction: Some medicines and supplements may affect blood sugar control, kidney function, or fluid balance. Their effects can vary depending on the specific product and your overall treatment plan.
Advice: Tell your doctor or pharmacist about all prescription medicines, over-the-counter products, and herbal supplements you use. Do not start or stop any medicine without professional guidance.
Important: Daparyl may increase the risk of dehydration and, in certain situations, diabetic ketoacidosis, even when blood sugar is not very high. Seek urgent medical attention for symptoms such as nausea, vomiting, abdominal pain, unusual tiredness, or difficulty breathing. Always follow your healthcare professional's instructions, particularly during illness, prolonged fasting, or before surgery.
| Manufacturer | : | Intas Pharmaceuticals Ltd |
| Equivalent Brand | : | Farxiga |
| Generic Search | : | Dapagliflozin |
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