Endace Tablet (Megestrol)

When taking Megestrol Tablet (Endace), it is important to be aware of certain precautions:

Pregnancy and Breastfeeding: Megestrol/Megace is contraindicated during pregnancy as it may harm the developing fetus. It is also not recommended for use while breastfeeding, as it may pass into breast milk and affect the nursing infant. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for alternative treatment options.

Allergies: Inform your healthcare provider if you have any known allergies or hypersensitivity to Megestrol or any other progestin medications. Allergic reactions to Megestrol are rare but can include rash, itching, swelling, severe dizziness, or difficulty breathing.

Medical Conditions: Discuss your medical history with your healthcare provider, especially if you have or have had a history of blood clots, liver disease, diabetes, heart disease, or any hormone-related conditions. Megestrol may worsen these conditions or interact with other medications used for their treatment.

Bone Health: Prolonged use of Megestrol may increase the risk of decreased bone density and osteoporosis, particularly in postmenopausal women. Regular monitoring of bone health may be recommended, and your healthcare provider may suggest measures to maintain bone strength, such as calcium and vitamin D supplementation.

Blood Sugar Levels: Megestrol can affect blood glucose levels and may increase the risk of developing or exacerbating diabetes. Regular monitoring of blood sugar levels is advised for individuals with diabetes or those at risk of developing diabetes.

Primary Application of Endace Tablet (Megestrol)

Cancer Treatment: Megestrol is commonly used in the treatment of certain types of cancers, including breast cancer and endometrial cancer. It can be prescribed as adjuvant therapy or for palliative care to help control the growth of cancer cells.

Anorexia and Cachexia: Megestrol has been found to be effective in stimulating appetite and promoting weight gain in patients suffering from anorexia and cachexia, which are conditions often associated with chronic illnesses like cancer or HIV/AIDS.

Hormone Replacement Therapy: Megestrol is a Life-Saving Drug, that may be prescribed as part of hormone replacement therapy for women experiencing menopausal symptoms, such as hot flashes and vaginal dryness. It can help alleviate these symptoms by providing progestational support.

Endometrial Hyperplasia: Megestrol/Megace is used in the treatment of endometrial hyperplasia, a condition characterized by the excessive growth of the lining of the uterus. It helps regulate the growth of the endometrial tissue and prevent the development of abnormal cells.

Birth Control: Megestrol can be used as a component of hormonal contraception, often in combination with other hormones like estrogen. It works by inhibiting ovulation and altering the uterine lining, thereby preventing pregnancy.

Like any medication, Megestrol Tablet (Endace) can cause Secondary effects.

Not everyone will experience these side effects, and their severity may vary among individuals. Common side effects may include:

Gastrointestinal Disturbances: Nausea, vomiting, diarrhea, or constipation may occur. Drinking plenty of fluids, eating smaller meals, and maintaining a healthy diet can help alleviate these symptoms.

Weight Gain: Megestrol/Megace can cause weight gain, which may be desirable in certain medical conditions but can be a concern for others. Maintaining a balanced diet and engaging in regular physical activity can help manage weight changes.

Fluid Retention: Some individuals may experience fluid retention, leading to swelling of the feet, ankles, or hands. If you notice sudden or severe swelling, contact your healthcare provider.

Changes in Libido: Megestrol may affect sexual desire or libido. Discuss any concerns with your healthcare provider if this side effect becomes bothersome.

Mood Changes: Megestrol can occasionally cause mood swings, anxiety, or depression. If you experience persistent or severe mood changes, consult your healthcare provider.

Hormonal Effects: Megestrol is a progestin medication and may cause hormonal effects such as breast tenderness, changes in menstrual cycle patterns, or vaginal bleeding. Inform your healthcare provider if you experience any abnormal bleeding or persistent discomfort.

Rare but Serious Side Effects: Although rare, Megestrol may cause serious side effects, including blood clots, liver problems, or allergic reactions. Seek immediate medical attention if you experience symptoms such as chest pain, shortness of breath, yellowing of the skin or eyes, or severe allergic reactions.

Queries About Megestrol Tablet (Endace) You May Occur

Can Megestrol Tablet (Endace) be used for birth control?

No, Megestrol Tablet is not intended for use as a standalone birth control method. It can be used as part of hormonal contraception when combined with other hormones like estrogen. However, it is important to consult with your healthcare provider to discuss and choose the most suitable and effective birth control option for your specific needs.

Can Megestrol Tablet/Megace interact with over-the-counter medications or herbal supplements?

Yes, Megestrol Tablet/Megace can interact with certain over-the-counter medications and herbal supplements. It is important to inform your healthcare provider about all the medications and supplements you are taking, including those without a prescription. This will help ensure there are no potential interactions that could affect the effectiveness or safety of your treatment.

Can Megestrol Tablet (Endace) be used for male patients?

While Megestrol is primarily used in the treatment of conditions in female patients, it can also be prescribed for specific indications in male patients. Your healthcare provider will determine if Megestrol is suitable for your particular medical condition and provide appropriate dosage instructions based on your specific needs.

Can Megestrol Tablet be used as a standalone treatment for cancer?

No, Megestrol Tablet is not typically used as a standalone treatment for cancer. It is often prescribed as part of a comprehensive treatment plan that may include surgery, radiation therapy, chemotherapy, or other anti-cancer medications. The use of Megestrol in cancer treatment is specific to certain types and stages of cancer, and your oncologist will determine the most appropriate treatment approach for your individual case.

Can Megestrol Tablet cause interactions with other neurology medications used for Parkinson's disease?

Megestrol Tablet does not have significant interactions with neurology medications commonly used for Parkinson's disease, such as levodopa or dopamine agonists. However, it is essential to inform your neurologist about all the medications you are taking, including Megestrol, to ensure proper management of your Parkinson's disease and to monitor for any potential drug interactions or effects on symptoms. Your healthcare providers can work together to adjust the treatment plan as needed to optimize your Parkinson's disease management.

Some notable drug interactions with Megestrol Tablet (Endace) include:

Megestrol Tablet (Endace) may interact with several medications, and it is crucial to inform your healthcare provider about all the drugs you are taking. 

Anti-Cancer Drugs: Megestrol may interact with certain anti-cancer medications, such as tamoxifen, anastrozole, or letrozole. These interactions can affect the effectiveness of the Anti-cancer treatment or increase the risk of side effects. Your healthcare provider will carefully monitor the combination therapy to ensure the best possible outcome.

Neurology Drugs: Megestrol/Megace can interact with certain neurology drugs, such as phenytoin or carbamazepine, used for the management of epilepsy or seizures. These interactions may alter the levels and effects of the neurology drugs, requiring dose adjustments or alternative treatment options. It is important to consult with both your oncologist and neurologist when using Megestrol in combination with neurology medications.

Anticoagulants: Megestrol can interact with anticoagulant medications, such as warfarin or heparin, used to prevent blood clotting. These interactions may increase the risk of bleeding or affect the anticoagulant's efficacy. Regular monitoring of blood clotting parameters is essential when combining Megestrol with anticoagulants.

Other Medications: Megestrol may interact with other medications, including corticosteroids, insulin, and oral hypoglycemic agents. These interactions can affect blood glucose control and may require adjustments in diabetes management.