Esperal Tablet (Disulfiram)

Disulfiram, commonly known by its brand name Esperal, is a medication used in the treatment of alcohol dependence. Antabuse is another brand name for Disulfiram.

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30 Tablet/s		$9.90
60 Tablet/s		$19.70
90 Tablet/s		$29.00

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What is Esperal Tablet (Disulfiram)?

Disulfiram, commonly known by its brand name Esperal, and Antabuse, is a medication used in the treatment of Alcohol Dependence. It belongs to a class of drugs known as alcohol aversion agents. Disulfiram is prescribed to individuals who have a history of alcohol abuse or dependence and want to remain sober by creating a strong aversion to alcohol consumption. When taken with alcohol, Disulfiram produces unpleasant effects that deter the individual from drinking, thereby helping them maintain sobriety. In this comprehensive guide, we will explore various aspects of Disulfiram, including dosage information, precautions, drug interactions, side effects, and its uses.

Dosage Information:

The dosage of Disulfiram may vary depending on individual factors such as the severity of alcohol dependence and the patient's overall health condition. It is essential to follow the doctor's prescribed dosage and not to alter the dosage without medical advice. Generally, the initial dosage of Disulfiram is 500 mg per day, but this may be adjusted based on the patient's response to the treatment. The tablet should be taken orally, with or without food. It is advisable to take Disulfiram in the morning to reduce the risk of potential adverse reactions if alcohol is consumed later in the day. The tablets should be swallowed whole and not crushed or chewed.

Disulfiram Contraindications:

Disulfiram is contraindicated in certain situations, and its use should be avoided in the following cases:
Patients actively consuming alcohol or with recent alcohol use should not take Disulfiram until they have abstained from alcohol for at least 12 hours.
Individuals with severe heart disease or a history of myocardial infarction (heart attack) should avoid Disulfiram due to potential cardiovascular risks.
Patients with known hypersensitivity or allergy to Disulfiram or any of its components should not use this medication.

Disulfiram Alternatives:

While Disulfiram is an effective medication for some individuals, there are other options available for the treatment of alcohol dependence. Some alternatives include:

Naltrexone: Naltrexone is a medication that reduces alcohol cravings and the pleasure associated with drinking. It is available in oral and injectable forms.

Acamprosate: Acamprosate helps maintain abstinence by reducing withdrawal symptoms and alcohol cravings.

Behavioral Therapy: Various behavioral therapies, such as cognitive-behavioral therapy (CBT) and motivational enhancement therapy, can be used alone or in combination with medication to treat alcohol dependence.

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Some of the precautionary measures to be taken while using Esperal Tablet (Disulfiram)

Informing your healthcare provider of any medical conditions or medications you are currently taking. Some medications and medical conditions may interact with Esperal and cause adverse reactions.
Avoiding alcohol in all forms, including cough medicine, mouthwash, and cooking wine. Consuming any amount of alcohol while taking Esperal can cause severe reactions, including vomiting, headache, and shortness of breath.
Monitoring for signs of liver problems, such as yellowing of the skin or eyes, abdominal pain, and dark urine. Esperal can cause liver damage in some individuals, so it is important to report any unusual symptoms to your healthcare provider immediately.
Discussing any mental health concerns with your healthcare provider. Esperal can cause depression, anxiety, and other mental health issues in some individuals.
Avoiding activities that require alertness until you know how Esperal affects you. Esperal can cause drowsiness and dizziness, which can impair your ability to drive or operate machinery.
Informing any healthcare provider who treats you that you are taking Esperal. This is important in case of a medical emergency or if you need to undergo surgery.
Overall, it is important to closely follow the guidance of your healthcare provider when using Esperal to treat alcoholism. This includes avoiding alcohol and monitoring for any unusual symptoms or side effects.

Some of the specific indications for Esperal Tablet (Disulfiram) include

Esperal (Disulfiram) is primarily used in the treatment of alcohol addiction. When taken as directed, it causes unpleasant reactions in the body when alcohol is consumed, which can help individuals overcome their Addiction by creating a negative association with alcohol. However, it is important to note that Esperal is not a cure for alcohol addiction and should be used in combination with counseling and other forms of support.
Esperal has also been studied for its potential use in the treatment of cocaine addiction, although this is less common. It is thought that Esperal may be effective in reducing cocaine use by inhibiting the enzyme dopamine beta-hydroxylase, which is involved in the metabolism of dopamine and norepinephrine.
Additionally, Esperal has been studied for its potential use in the treatment of certain types of cancer, although more research is needed in this area. It has been found to have some anti-tumor effects in animal studies, although it is not currently used as a standard treatment for cancer.
Esperal may also have potential use in the treatment of Lyme disease, as it has been found to have some antibacterial properties. However, more research is needed in this area to determine its effectiveness and safety.
It should only be used under the guidance and supervision of a healthcare provider who is experienced in the treatment of addiction.

Important Secondary Effects of Esperal Tablet (Disulfiram)

Esperal Tablet (Disulfiram) can cause side effects, some of which may be serious. The most common side effects include:

Nausea and vomiting
Headache
Dizziness
Fatigue
Skin rash

In rare cases, more serious side effects can occur, such as:

Liver damage
Mental confusion
Seizures

If you experience any concerning symptoms while taking Esperal Tablet, it is important to seek medical attention immediately. It is also important to inform your healthcare provider of any side effects you experience while taking Esperal Tablet, as they may need to adjust your treatment plan.

It is important to avoid consuming any products that contain alcohol, including mouthwash and cough syrup while taking Esperal Tablet, as this can lead to unpleasant side effects.

Answers to Common Inquiries - Esperal Tablet (Disulfiram)

What is Esperal Tablet?

Esperal Tablet is a medication used in the treatment of alcohol addiction. The active ingredient in Esperal Tablet is disulfiram, which works by causing unpleasant physical symptoms when alcohol is consumed, thus discouraging the individual from drinking alcohol.

How does Esperal Tablet work?

Esperal Tablet works by inhibiting the activity of an enzyme called acetaldehyde dehydrogenase, which is responsible for breaking down alcohol in the body. When alcohol is consumed while taking Esperal Tablet, it causes a buildup of a toxic substance called acetaldehyde, which leads to a range of unpleasant symptoms such as nausea, vomiting, headache, and palpitations. These symptoms are intended to discourage the individual from consuming alcohol.

Is Esperal Tablet effective in treating alcohol addiction?

Esperal Tablets can be effective in treating alcohol addiction, particularly when used as part of a comprehensive treatment program that includes counseling and support. However, it is important to note that Esperal Tablet is not a cure for alcohol addiction and should only be used under the guidance of a healthcare professional.

Is Esperal Tablet addictive?

No, Esperal Tablet is not addictive. It does not produce feelings of euphoria or pleasure and is not habit-forming. However, it is important to follow the dosing instructions provided by your healthcare provider and to only take Esperal Tablet as directed.

How should Esperal Tablet be taken?

Esperal tablets should be taken exactly as prescribed by your healthcare provider. Typically, it is taken once daily in the morning, with or without food. It is important to avoid consuming any products that contain alcohol while taking Esperal Tablet, as this can lead to unpleasant side effects. If you miss a dose of Esperal Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Combining different drugs with Esperal Tablet (Disulfiram) can lead to Adverse Effects

There are several medications and substances that can interact with Esperal (Disulfiram), potentially causing serious side effects. These interactions include:

Alcohol: Consuming any amount of alcohol while taking Esperal can cause severe reactions, including vomiting, headache, and shortness of breath.
Antabuse-like drugs: Other drugs that work similarly to Esperal, such as calcium carbimide, can interact with Esperal and cause severe reactions.
Warfarin: Esperal can increase the effects of warfarin, a blood-thinning medication, increasing the risk of bleeding.
Benzodiazepines: Combining Esperal with benzodiazepines, such as diazepam or lorazepam, can increase the risk of sedation and respiratory depression.
Antidepressants: Esperal can interact with certain antidepressants, such as fluoxetine and paroxetine, increasing the risk of serotonin syndrome, a potentially life-threatening.