Abamune-L Tablet (Abacavir + Lamivudine)

Abacavir + Lamivudine Tablet, commonly known by its brand name Abamune-L and Epzicom is a combination medication used to treat HIV (Human Immunodeficiency Virus) infection. It contains two active ingredients: Abacavir and Lamivudine.

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Abamune-L Tablet (Abacavir 600mg + Lamivudine 300mg)

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30 Tablet/s $68.00
60 Tablet/s $129.00
90 Tablet/s $187.00

Introduction to Abacavir + Lamivudine Tablet (Abamune-L)

Abacavir + Lamivudine Tablet, commonly known by its brand name "Abamune-L," is a combination medication used to treat HIV (Human Immunodeficiency Virus) infection. It contains two active ingredients: Abacavir and Lamivudine. These antiviral drugs belong to the class of nucleoside reverse transcriptase inhibitors (NRTIs), which work by inhibiting the reverse transcriptase enzyme responsible for HIV replication. Abamune-L is primarily prescribed to patients diagnosed with HIV-1, a specific strain of the virus that causes acquired immunodeficiency syndrome (AIDS). Epzicom is another brand name for the combination of Abacavir + Lamivudine Tablet (Abamune-L). The medication is marketed under various brand names by different pharmaceutical companies to ensure wider availability and accessibility.

Dosage Information

Abamune-L tablets are available in various strengths, and the dosage may vary depending on the patient's individual condition, medical history, and response to the treatment. It is essential to follow the healthcare provider's instructions regarding the dosage and duration of the medication. Typically, the recommended dosage for adults and adolescents weighing 25 kg (55 lbs) or more is one tablet of Abamune-L once daily, with or without food. For pediatric patients weighing less than 25 kg (55 lbs), the dosage may be adjusted based on body weight and should be administered under medical supervision. It is crucial to take Abamune-L regularly and at the same time each day to maintain consistent drug levels in the bloodstream and achieve optimal therapeutic effects. Missing doses or altering the prescribed dosage without medical advice may lead to treatment failure and the development of drug-resistant strains of the virus.

Abacavir and Lamivudine Tablets Brand Names: Apart from Epzicom and Abamune-L, Abacavir + Lamivudine Tablets may be sold under different brand names by various manufacturers. Some examples include Kivexa, Trizivir, and Triumeq. Patients should always check the brand name on their medication packaging and verify it with their healthcare provider to ensure consistency in treatment.

Abacavir Lamivudine Combination Tablet: Abacavir Lamivudine Combination Tablet refers to the combination of Abacavir and Lamivudine in a single pill, such as Abamune-L. This combination offers the advantage of simplified dosing, increased convenience, and potentially improved adherence to the treatment plan.

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When Using Abamune-L Tablet (Abacavir + Lamivudine), It Is Important To Take Certain Precautions

  • Allergy Testing: Before initiating treatment with Abacavir + Lamivudine Tablet (Abamune-L/Epzicom), it is crucial for patients to undergo an HLA-B5701 genetic screening. Abacavir, one of the active ingredients in Abamune-L, is associated with a severe hypersensitivity reaction in individuals carrying the HLA-B5701 allele. If a patient tests positive for this genetic marker, alternative HIV medications should be prescribed to avoid the risk of a potentially life-threatening hypersensitivity reaction.
  • Hypersensitivity Reaction: Even in the absence of the HLA-B*5701 allele, Abamune-L may still cause a hypersensitivity reaction in some individuals. Symptoms of hypersensitivity include fever, skin rash, nausea, vomiting, fatigue, and respiratory distress. If any signs of a hypersensitivity reaction occur, immediate medical attention is necessary. Discontinuing Abamune-L and avoiding re-administration is essential to prevent a more severe reaction.
  • Hepatic Impairment: Patients with underlying liver conditions should exercise caution while taking Abacavir + Lamivudine Tablet. Close monitoring of liver function and adjustment of the dosage may be required in patients with impaired liver function.
  • Renal Impairment: Individuals with kidney problems should be closely monitored during Abamune-L treatment. Dosage adjustments may be necessary to prevent drug accumulation and potential side effects.
  • Cardiovascular Risk: Some antiretroviral medications, including Abamune-L, have been associated with an increased risk of cardiovascular events. Patients with pre-existing cardiovascular conditions should discuss the potential risks and benefits of treatment with their healthcare provider.
  • Lactic Acidosis: Rare cases of lactic acidosis, a serious metabolic complication, have been reported with the use of NRTIs, including Lamivudine. Patients experiencing symptoms such as rapid breathing, muscle pain, abdominal discomfort, or dizziness should seek immediate medical attention.
  • Immune Reconstitution Inflammatory Syndrome (IRIS): In HIV-infected patients with severe immune deficiency, Abamune-L treatment may result in the rapid improvement of immune function. This can lead to inflammatory responses to previously occult infections. Patients should be monitored for signs of IRIS, and appropriate treatment should be initiated promptly.

Some of the specific indications for Abacavir + Lamivudine Tablet (Abamune-L) include

  • HIV Treatment: Abamune-L is a Life-Saving Drug, a vital component of combination antiretroviral therapy (ART) used to manage HIV infection. When used in conjunction with other antiretroviral medications, it helps suppress viral replication, reduce viral load, and improve the immune function of HIV-infected individuals. This can lead to a decrease in HIV-related complications and delay the progression of AIDS.
  • Prevention of Mother-to-Child Transmission: Pregnant women living with HIV may be prescribed Abamune-L/Epzicom as part of the prevention of mother-to-child transmission (PMTCT) program. By reducing viral replication, the medication helps lower the risk of transmitting the virus from the mother to her baby during pregnancy, labor, and breastfeeding.
  • Post-Exposure Prophylaxis (PEP): Abamune-L, when used as part of PEP, can be administered to individuals at high risk of HIV infection after potential exposure. Timely initiation of PEP within 72 hours of exposure can significantly reduce the risk of acquiring HIV.
  • Occupational Exposure Prophylaxis (PEP): Healthcare workers or individuals who experience accidental needle-stick injuries or other potential exposures to HIV in the workplace may be prescribed Abamune-L as a preventive measure.
  • Combination Therapy Convenience: Abacavir + Lamivudine Tablet provides the convenience of a fixed-dose combination, reducing the number of pills an individual needs to take daily. This can improve medication adherence, which is crucial for the success of HIV treatment.

Some of the secondary effects of Abamune-L Tablet (Abacavir + Lamivudine)

Hypersensitivity Reaction: A severe and potentially life-threatening hypersensitivity reaction, characterized by fever, skin rash, gastrointestinal symptoms, and respiratory distress, may occur with Abamune-L use. Immediate medical attention is required if such symptoms appear.

Lactic Acidosis: As mentioned earlier, lactic acidosis is a rare but serious side effect of NRTIs, including Lamivudine. Symptoms may include rapid breathing, muscle pain, abdominal discomfort, and dizziness.

Hepatotoxicity: Abamune-L/Epzicom may cause liver damage in some patients, leading to symptoms like jaundice, dark urine, and abdominal pain. Regular monitoring of liver function is necessary during treatment.

Immune Reconstitution Syndrome: Some individuals may experience immune reconstitution inflammatory syndrome (IRIS), leading to the worsening of pre-existing infections upon starting antiretroviral therapy.

Gastrointestinal Disturbances: Nausea, vomiting, diarrhea, and abdominal pain are common side effects of Abamune-L. Taking the medication with food may help alleviate these symptoms.

Headache and Fatigue: Some patients may experience headaches and fatigue during the initial phase of treatment. These side effects usually subside over time.

Insomnia: Abacavir has been associated with sleep disturbances in some individuals, leading to insomnia.

Peripheral Neuropathy: In rare cases, prolonged use of Lamivudine may cause peripheral neuropathy, characterized by tingling or numbness in the hands and feet.

Changes in Body Fat: Antiretroviral therapy, including Abamune-L, may lead to changes in body fat distribution, such as fat accumulation in the abdomen, breasts, or back of the neck.

FAQs about Abacavir + Lamivudine Tablet (Abamune-L)

FAQ 1: Can Abamune-L cure HIV completely?

Answer: No, Abamune-L cannot cure HIV. It is an antiretroviral medication that helps suppress viral replication and manage HIV infection. It is essential to take the medication consistently and as prescribed to control the virus and improve immune function.

FAQ 2: Are there any specific food restrictions while taking Abamune-L/Epzicom?

Answer: Abamune-L/Epzicom can be taken with or without food. However, taking it with food may help reduce gastrointestinal side effects, such as nausea and vomiting. Patients should avoid consuming alcohol or grapefruit juice, as they may interact with the medication and affect its efficacy.

FAQ 3: Can pregnant women take Abamune-L?

Answer: Pregnant women living with HIV may be prescribed Abamune-L as part of the prevention of mother-to-child transmission (PMTCT) program. However, the decision to use the medication during pregnancy should be made under the guidance of a healthcare provider, considering potential risks and benefits.

FAQ 4: Can I switch to a different brand of Abacavir + Lamivudine tablets?

Answer: Yes, there are multiple brands of Abacavir + Lamivudine tablets available in the market. However, patients should not switch medications without consulting their healthcare provider. Different brands may have variations in dosage, formulation, and inactive ingredients, which can affect treatment outcomes.

FAQ 5: What should I do if I miss a dose of Abamune-L?

Answer: If you miss a dose, take it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not take a double dose to compensate for the missed one. It is essential to maintain consistent drug levels in the bloodstream for effective HIV management.

Important Drug Interconnections with Abamune-L Tablet (Abacavir + Lamivudine) must be noticed

  • Other Antiretrovirals: When Abamune-L is used in combination with other antiretroviral drugs, there is a potential for drug interactions. Healthcare providers must be aware of all medications the patient is taking to avoid adverse effects or reduced drug efficacy.
  • Methadone: Co-administration of Abacavir and Lamivudine/Epzicom with methadone, a medication used for opioid addiction treatment, may alter methadone levels in the blood. Dose adjustments of methadone may be required to prevent withdrawal symptoms or methadone toxicity.
  • Sorbitol-Containing Medications: Lamivudine, one of the components of Abamune-L, may interact with sorbitol-containing medications, leading to gastrointestinal disturbances. Patients should inform their healthcare providers if they are taking any sorbitol-containing medications.
  • Ribavirin: Concomitant use of Abamune-L with ribavirin, a medication used to treat hepatitis C, may increase the risk of anemia. Regular monitoring of blood cell counts is necessary when using these medications together.
  • Other Medications: Abamune-L may interact with various other medications, including certain antibiotics, antifungal agents, and drugs that affect the liver. Patients should provide a complete list of all medications, including over-the-counter drugs and herbal supplements, to their healthcare providers.
More Information Demo
Manufacturer : Cipla Pharma, India
Equivalent Brand : Epzicom
Generic Search : Abacavir + Lamivudine