Diabetrol SR Tablet (Glibenclamide + Metformin)

Essential Safety Advice to Follow when Using Glucovance/Diabetrol SR Tablet (Glibenclamide + Metformin)

• Kidney Function: Prior to initiating Diabetrol, kidney function should be assessed, as Metformin can accumulate in individuals with impaired kidney function, increasing the risk of adverse effects.
• Liver Function: Liver function tests are advisable, given the role of the liver in Metformin metabolism.
• Hypersensitivity: Anyone with a history of hypersensitivity to sulfonylureas or Metformin should avoid Diabetrol.
• Surgery and Imaging: If surgery or procedures requiring contrast dye are planned, Diabetrol may need to be temporarily discontinued due to the risk of lactic acidosis.
• Pregnancy and Breastfeeding: Diabetrol usage during pregnancy and breastfeeding requires careful evaluation, as both Glibenclamide and Metformin cross the placenta and are excreted in breast milk.

Some of the specific indications for Glucovance/Diabetrol SR Tablet (Glibenclamide + Metformin) include

• Type 2 Diabetes Management: Diabetrol is primarily indicated for individuals with type 2 diabetes to help lower blood sugar levels.
• Glycemic Control: Glibenclamide stimulates the release of insulin from the pancreas, while Metformin improves insulin sensitivity and reduces glucose production in the liver.
• Combination Approach: The combination of these two medications addresses multiple pathways of glucose regulation, resulting in more effective diabetes management.
• Long-term Benefits: By controlling blood sugar levels, Diabetrol helps prevent diabetes-related complications such as neuropathy, nephropathy, and retinopathy.
• Metabolic Health: Beyond glucose control, Diabetrol may contribute to weight management and improved lipid profiles.

Some of the Secondary Effects of Diabetrol SR Tablet (Glibenclamide + Metformin)

• Hypoglycemia: Glibenclamide can cause low blood sugar, leading to symptoms like sweating, tremors, and confusion.
• Gastrointestinal Issues: Metformin might cause stomach upset, diarrhea, and nausea, especially when treatment starts.
• Lactic Acidosis: Although rare, Metformin can lead to a serious condition called lactic acidosis, characterized by muscle pain, weakness, and respiratory problems.
• Allergic Reactions: Individuals allergic to sulfonylureas (a class of drugs that includes glibenclamide) might experience skin rashes, itching, and swelling.
• Vitamin B12 Deficiency: Long-term Metformin use may reduce vitamin B12 absorption, potentially causing anemia and neuropathy.

Queries and Answers About Diabetrol SR Tablet (Glibenclamide + Metformin)

Can I take Diabetrol if I have kidney issues?

It's essential to consult your doctor. Kidney function impacts Metformin clearance, which could lead to adverse effects. Your healthcare provider will determine if Diabetrol is suitable for you.

Is Diabetrol safe for older adults?

Diabetrol's use in older adults requires caution. The doctor may adjust the dosage due to potential age-related kidney function changes and the risk of hypoglycemia.

Can I switch to Diabetrol from other diabetes medications?

Transitioning between diabetes medications should be guided by a healthcare professional. Diabetrol's dual mechanism differs from single agents, and adjustments are necessary for a safe switch.

Does Diabetrol affect vitamin B12 levels?

Yes, long-term Metformin use might lead to lower vitamin B12 levels. Periodic monitoring and supplementation may be recommended to address potential deficiencies.

Can I exercise while taking Diabetrol?

Regular exercise is beneficial for managing diabetes, but when combined with Diabetrol, there's a need to monitor blood sugar levels closely to prevent episodes of hypoglycemia.

Significant Drug Interactions that Require Attention For Diabetrol SR Tablet (Glibenclamide + Metformin)

• Alcohol: Alcohol consumption can potentiate the risk of lactic acidosis associated with Metformin.
• Beta-Blockers: Certain beta-blockers can mask the symptoms of hypoglycemia, making blood sugar management challenging.
• Diuretics: Some diuretics can lead to electrolyte imbalances, which may interact with Metformin's mechanism of action.
• NSAIDs: Non-steroidal anti-inflammatory drugs (NSAIDs) can affect blood sugar levels and increase the risk of hypoglycemia.
• Cimetidine: Cimetidine, used for stomach ulcers, can interfere with Metformin's clearance, potentially leading to higher blood levels.